Guiding Value of Urinary Tumor DNA Testing in Repeat Transurethral Resection of Non-Muscle-Invasive Bladder Cancer

NARecruitingINTERVENTIONAL
Enrollment

196

Participants

Timeline

Start Date

July 1, 2025

Primary Completion Date

July 1, 2027

Study Completion Date

October 1, 2027

Conditions
Bladder CancerLiquid BiopsyRepeat Transurethral Resection of Bladder Tumor
Interventions
PROCEDURE

Second Transurethral Resection of Bladder Tumor (re-TURBT)

Participants with NMIBC who have undergone initial TURBT will not receive utDNA testing and will undergo a second transurethral resection of bladder tumor (re-TURBT) within 2-6 weeks after the initial surgery, in accordance with current clinical guidelines.

DIAGNOSTIC_TEST

utDNA Testing (Urine Tumor DNA Detection)

"Participants with NMIBC who have undergone initial TURBT will receive urine tumor DNA (utDNA) testing.~If utDNA is positive, the patient will undergo a second transurethral resection of bladder tumor (re-TURBT) within 2-6 weeks after the initial surgery.~If utDNA is negative, re-TURBT will be omitted and patients will proceed to guideline-based adjuvant therapy or surveillance."

Trial Locations (1)

300000

RECRUITING

The second hospital of Tianjin Medical University, Tianjin

All Listed Sponsors
lead

Tianjin Medical University Second Hospital

OTHER