Driving Pressure During Surgeries With High Risk for Postoperative Pulmonary Complications

NANot yet recruitingINTERVENTIONAL
Enrollment

200

Participants

Timeline

Start Date

October 1, 2025

Primary Completion Date

August 31, 2027

Study Completion Date

November 30, 2027

Conditions
Postoperative Pulmonary AtelectasisPostoperative Pulmonary ComplicationsPostoperative Respiratory FailurePostoperative BronchospasmPostoperative Pleural EffusionPostoperative PneumothoraxPostoperative PneumoniaPostoperative Aspiration PneumonitisMechanical PowerDriving Pressure
Interventions
PROCEDURE

PEEP titration for Minimum Driving Pressure

"This group is mechanically ventilated with Invasive Mechanical Ventilation with Volume Control Ventilation mode with PEEP Initially 8 cm H2O. Afterwards, the lungs are recruited with the aforementioned maneuver. During subsequent derecruitment, PEEP is decreased by 2 cm H20 and compliance is noted in each stage. The goal is to find PEEP with maximum compliance (Cmax). A new recruitment maneuver follows and during derecruitment PEEP is set at the optimum value that was previously defined.~VT 8 ml/kg IBW RR --\> PaCO2 = 35-45 mmHg FiO2 0.4 - 0.5 --\> SpO2 \> 93% Recruitment Maneuver (as described) every hour"

PROCEDURE

Lung Protective Ventilation

This group is mechanically ventilated with Invasive Mechanical Ventilation with Volume Control Ventilation mode with PEEP 8 cm H2O. VT 8 ml/kg IBW RR --\> PaCO2 = 35-45 mmHg FiO2 0.4 - 0.5 --\> SpO2 \> 93% Recruitment Maneuvers (as described) every hour

All Listed Sponsors
lead

University General Hospital of Patras

OTHER

NCT07186933 - Driving Pressure During Surgeries With High Risk for Postoperative Pulmonary Complications | Biotech Hunter | Biotech Hunter