LY4268989 (MORF-057) Co-Administered With Mirikizumab in Adults With Moderately to Severely Active Ulcerative Colitis:

PHASE2Not yet recruitingINTERVENTIONAL
Enrollment

252

Participants

Timeline

Start Date

November 30, 2025

Primary Completion Date

May 31, 2027

Study Completion Date

March 31, 2029

Conditions
Ulcerative Colitis
Interventions
DRUG

LY4268989

Administered PO

DRUG

Mirikizumab

Administered IV then SC

DRUG

LY4268989 Placebo

Administered PO

Trial Locations (146)

1036

Óbudai Egészségügyi Centrum, Budapest

1088

Semmelweis Egyetem, Budapest

1090

Medizinische Universität Wien, Vienna

1136

Pannónia Magánorvosi Centrum, Budapest

2600

Jávorszky Ödön Kórház, Vác

2730

Herlev and Gentofte Hospital, Copenhagen

2800

Komarom-Esztergom Varmegyei Szent Borbala Korhaz, Tatabánya

3200

Clinexpert Gyöngyös, Gyöngyös

5000

Odense Universitetshospital, Odense

5020

Uniklinikum Salzburg, Salzburg

5600

Békés Megyei Központi Kórház Dr. Réthy Pál Tagkórház, Békéscsaba

8200

Aarhus Universitetshospital, Skejby, Aarhus

9000

Aalborg Universitetshospital, Syd, Aalborg

10032

Columbia University Irving Medical Center, New York

10117

Charité Universitaetsmedizin Berlin - Campus Mitte, Berlin

13502

Digestive Disease Medicine of Central New York, Utica

14050

Medimanage Research, Tlalpan

14080

Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, Mexico City

20089

Humanitas, Rozzano

20122

Fondazione IRCCS Cà Granda Ospedale Maggiore Policlinico, Milan

20132

Ospedale San Raffaele, Milan

20162

ASST Grande Ospedale Metropolitano Niguarda, Milan

21200

Dicle Üniversitesi, Sur

22105

Scientia Investigacion Clinica S.C., Tijuana

23226

Clinical Research Partners, LLC, Richmond

23229

GI Alliance - Richmond, Richmond

26480

Eskisehir Osmangazi University, Eskişehir

28046

Hospital Universitario La Paz, Madrid

28942

Hospital Universitario de Fuenlabrada, Fuenlabrada

29607

Gastroenterology Associates, P.A. of Greenville, Greenville

31030

Mustafa Kemal Universitesi, Hatay

31207

Scientia Investigacion Clinica S.C., Chihuahua City

32256

Encore Borland-Groover Clinical Research, Jacksonville

32825

Digestive and Liver Center of Florida, Orlando

33016

NeoClinical Research, Hialeah

33063

Atlantic Medical Research, Margate

33064

Alliance Medical Research, Lighthouse PT

33110

Mersin University, Mersin

33394

Hospital de Cabueñes, Gijón

34000

Instituto de Investigaciones Aplicadas a la Neurociencia A.C., Durango

34211

Florida Research Institute, Lakewood Rch

34741

Clinical Research of Osceola, Kissimmee

38010

Hospital Universitario Nuestra Señora de Candelaria, Santa Cruz de Tenerife

38018

Gastro One - Walnut Run Road, Cordova

39232

GI Associates - GIA and Endoscopy Center - Flowood, Flowood

40218

Gastroenterology Health Partners, Louisville

41380

Kocaeli University Medical Faculty Hospital, İzmit

44280

İnönü Üniversitesi Turgut Özal Tıp Merkezi Eğitim ve Araştırma Hastanesi, Malatya

44600

Boca Clinical Trials Mexico S.C., Guadajalara

44650

Clinica de Investigacion en Reumatologia y Obesidad S. C., Guadalajara

44718

Gastroenterology & Hepatology Specialists, Canton

45415

Dayton Gastroenterology, LLC, Dayton

47150

Gastroenterology Health Partners, New Albany

48038

Clinical Research Institute of Michigan, LLC, Clinton Township

54055

Clinical Research Institute S.C., Tlalnepantla

60016

Lakeshore Gastroenterology and Liver Disease Institute, Des Plaines

60026

GI Alliance - Glenview, Glenview

60031

Gi Alliance - Gurnee, Gurnee

62223

Center for Gastrointestinal Health - Fairview Heights, Belleville

66220

Servicios de Oncología Médica Integral - Monterrey, San Pedro Garza García

75044

GI Alliance - Garland, Garland

75246

GI Alliance - Dallas - Gaston Avenue, Dallas

75701

Tyler Research Institute, Tyler

76104

GI Alliance - Fort Worth, Fort Worth

77598

GI Alliance-Webster, Webster

78229

Southern Star Research Institute, San Antonio

78613

Texas Digestive Disease Consultants - Cedar Park, Cedar Park

79410

GI Alliance - Lubbock, Lubbock

80907

Peak Gastroenterology Associates, Colorado Springs

84403

Care Access - Ogden, Ogden

85259

Mayo Clinic in Arizona - Scottsdale, Scottsdale

90035

Biopharma Informatic, LLC, Los Angeles

91900

FAICIC S. de R.L. de C.V., Veracruz

92805

Clinnova Research - Anaheim, Anaheim

93053

Universitätsklinikum Regensburg, Regensburg

93534

Om Research LLC, Lancaster

98004

Washington Gastroenterology - Bellevue, Bellevue

110004

Shengjing Hospital of China Medical University, Shenyang

110029

All India Institute of Medical Sciences, New Delhi

210029

Jiangsu Province Hospital, Nanjing

213000

Changzhou Second People's Hospital, Changzhou

214023

Wuxi People's Hospital, Wuxi

266003

The Affiliated Hospital of Qingdao University, Qingdao

271000

Taian City Central Hospital, Taian

300002

S.C Centrul de Gastroenterologie Dr. Goldis S.R.L, Timișoara

310018

Sir Run Run Shaw Hospital of Zhejiang University School of Medicine, Hangzhou

350005

The First Affiliated Hospital Of Fujian Medical University, Fuzhou

360005

Shree Giriraj Multispeciality Hospital, Rajkot

380006

Sardar Vallabhbhai Patel Institute of Medical Sciences and Research, Ahmedabad

401147

Chongqing General Hospital, Chongqing

411007

Medipoint Hospitals Pvt. Ltd., Pune

430022

Wuhan Union Hospital, Wuhan

440055

Spital Judetean de Urgenta, Satu Mare

500004

Mahavir Hospital & Research Centre - Hyderabad, Hyderabad

580021

Sushruta Multispeciality Hospital & Research Centre, Hubli

600003

Rajiv Gandhi Government General Hospital, Chennai

641012

Ashwin Hospital, Coimbatore

650032

First Affiliated Hospital of Kunming Medical University, Kunming

900591

Constanta County Emergency Clinical Hospital Sf.Ap.Andrei, Constanța

02215

Brigham and Women's Hospital, Boston

02904

University Gastroenterology - Providence - West River Street, Providence

72145-450

Chronos Pesquisa Clínica, Brasília

13087-567

CAEP - Synvia Labs, Campinas

95070-560

Fundação Universidade de Caxias do Sul (FUCS), Caxias do Sul

80430-180

Centro Digestivo de Curitiba, Curitiba

36033-318

Galileo Medical Research, Juiz de Fora

57020-360

NewData Clinical Research - Maceió, Maceió

90160-092

Hospital Ernesto Dornelles, Porto Alegre

12230-001

Centro Internacional de Pesquisa Clínica (CIPES), São José dos Campos

01228-000

CPQuali Pesquisa Clínica, São Paulo

01307-002

Solare Trials, São Paulo

01310-000

Hospital Santa Catarina - Paulista, São Paulo

04543-011

Clínica Hepatogastro JK, São Paulo

64049-550

Universidade Federal Do Piaui - Campos Universitario, Teresina

L8N 1Y2

Charlton Digestive Disease Centre, Hamilton

N6A 5W9

Victoria Hospital & Children's Hospital - London Health Sciences Centre, London

N6K 1M6

London Digestive Disease Institute, London

L5M 2S4

West GTA Research Inc., Mississauga

G8T 7A1

C.I.C. Mauricie inc., Trois-Rivières

050000

The Second Afilliated Hospital of Hebei Medical University, Shijiazhuang

00168

Fondazione Policlinico Universitario Agostino Gemelli, Roma

814-0180

Fukuoka University Hospital, Fukuoka

247-0056

Gokeikai Ofuna Chuo Hospital, Kamakura

273-0011

Tsujinaka Hospital - Kashiwanoha, Kashiwa

540-0006

National Hospital Organization Osaka National Hospital, Osaka

285-8741

Toho University Sakura Medical Center, Sakura

004-0041

Sapporo Tokushukai Hospital, Sapporo

03330

Centro de Investigación y Gastroenterología - S.C., Mexico City

04100

Centro de Investigación Clinica Chapultepec, Mexico City

6525 GA

Radboudumc, Nijmegen

5022 GC

Elisabeth-TweeSteden Ziekenhuis, Tilburg

40-600

Gyncentrum sp. z o.o. NZOZ Holsamed - oddział Libero, Katowice

97-300

IRMED, Piotrkow Trybunalski

60-192

Pratia Poznań, Poznan

60-354

Uniwersyteckie Centrum Stomatologii i Medycyny Specjalistycznej, Poznan

71-434

Twoja Przychodnia SCM, Szczecin

71-685

Sonomed Sp. z o. o., Szczecin

02-786

WSD MEDI, Warsaw

04-501

Medical Network Spółka z o.o. WIP Warsaw IBD Point Profesor Kierkuś, Warsaw

22-400

ETG Zamość, Zamość

013823

Spitalul de Oncologie Monza, Bucharest

014142

Delta Health Care, Bucharest

020125

Spitalul Clinic Colentina, Bucharest

08022

Centro Médico Teknon, Barcelona

Unknown

Adana City Hospital, Adana

07100

Antalya Egitim ve Arastırma Hastanesi, Antalya

All Listed Sponsors
lead

Eli Lilly and Company

INDUSTRY