100
Participants
Start Date
October 1, 2025
Primary Completion Date
December 1, 2027
Study Completion Date
December 31, 2027
Desmopressin after protamine reversal
"Desmopressin will be given to participants at a dose of 0.3mcg/kg after protamine reversal at the end of cardiopulmonary bypass (CPB).~Platelet function will be assessed by TEG (Thromboelastography) platelet mapping at the following points:~1. T1 TEG6s: after arterial line insertion before skin incision.~2. T2 TEG6s: after protamine (baseline function after CPB)~3. T3 TEG6s: 30 minutes after desmopressin~4. T4 TEG6s: 6 hours after (intensive care unit) ICU admission~5. T5 TEG6s: 24hours after ICU admission"
London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
OTHER