Endoscopic Cardial Constriction Ligation (ECCL) for Refractory GERD Using a Disposable Endoscope

NANot yet recruitingINTERVENTIONAL
Enrollment

46

Participants

Timeline

Start Date

October 1, 2025

Primary Completion Date

June 30, 2028

Study Completion Date

June 30, 2028

Conditions
Gastroesophageal Reflux Disease (GERD)
Interventions
PROCEDURE

endoscopic cardia constriction ligation

The experimental group used disposable endoscopes to perform ECCL, while the control group used traditional endoscopes to perform ECCL. ECCL involves ligating and fixing the mucosa and partial muscle layer above the dentate line under direct endoscopic visualization to create folds. Post-procedure, the ligated mucosa undergoes ischemic necrosis and heals to form scar tissue, thereby reducing the cardia diameter, increasing LES pressure, and alleviating reflux symptoms.

Trial Locations (1)

510515

Shenzhen Hospital of Southern Medical University, Shenzhen

All Listed Sponsors
lead

Ying Zhu

OTHER

NCT07176221 - Endoscopic Cardial Constriction Ligation (ECCL) for Refractory GERD Using a Disposable Endoscope | Biotech Hunter | Biotech Hunter