γδ T-PD-1 Ab Cells in the Treatment of Malignant Meningioma

EARLY_PHASE1Not yet recruitingINTERVENTIONAL
Enrollment

12

Participants

Timeline

Start Date

October 15, 2025

Primary Completion Date

October 31, 2028

Study Completion Date

October 31, 2029

Conditions
Malignant Meningioma
Interventions
BIOLOGICAL

γδ T-PD-1 Ab cells

Patients will receive 6 cycles of ex-vivo expanded γδ T-PD-1 Ab cells treatments,at two-weeks' intervals.γδ T-PD-1 Ab cells are injected through the Ommaya device in a typical 3+3 dose-escalation design(Dose escalation, 1×10\^7, 3×10\^7, 1×10\^8).

Sponsors
All Listed Sponsors
lead

Nanjing Medical University

OTHER