A MULTICENTER STUDY TO OPTIMIZE MICROEMBOLIC SIGNAL CLASSIFICATION BASED ON DOUBLE-BLIND MULTIPARAMETRIC ASSESSMENT BY HUMAN EXPERTS USING AN UNIVERSAL GRAPHICAL INTERFACE [MESOMEGA]

Expert reading will be using TCDPlayer and will be blinded to clinical data, source information, and other assessments. They will manually annotate six predefined signal features: characteristic audible signal increase, characteristic wave-like of raw Doppler signals, Emboli-to-Background Ratio, Emboli-to-Mirror Ratio, signal duration, and average velocity of maximum intensity. Analysis will be completed within 90 days.