A Study of Orforglipron (LY3502970) in Participants With Obesity or Overweight and Osteoarthritis (OA) of the Knee

PHASE3RecruitingINTERVENTIONAL
Enrollment

800

Participants

Timeline

Start Date

September 15, 2025

Primary Completion Date

April 30, 2028

Study Completion Date

May 31, 2028

Conditions
Osteoarthritis
Interventions
DRUG

Orforglipron

Administered orally

DRUG

Placebo

Administered orally

Trial Locations (91)

10117

NOT_YET_RECRUITING

Klinische Forschung Berlin-Mitte, Berlin

15006

NOT_YET_RECRUITING

Hospital San Rafael - La Coruña, A Coruña

15702

NOT_YET_RECRUITING

Clínica Gaias - Santiago, Santiago de Compostela

16602

NOT_YET_RECRUITING

University Orthopedics Center, Altoona

20095

NOT_YET_RECRUITING

HRF II - Hamburger Rheuma Forschungszentrum II MVZ für Rheumatologie und Autoimmunmedizin Hamburg GmbH / -T, Hamburg

20253

NOT_YET_RECRUITING

Klinische Forschung Hamburg, Hamburg

21100

NOT_YET_RECRUITING

Centro Medico del Angel, Mexicali

22911

RECRUITING

Charlottesville Medical Research, Charlottesville

23454

RECRUITING

Gershon Pain Specialists, Virginia Beach

24768

NOT_YET_RECRUITING

Private Practice - Dr. Jochen Walter, Rendsburg

28150

NOT_YET_RECRUITING

Carolina Research Center, Shelby

29004

NOT_YET_RECRUITING

Hospital Quirón Málaga, Málaga

30030

NOT_YET_RECRUITING

Care Access - Decatur, Decatur

30159

NOT_YET_RECRUITING

Klinische Forschung Hannover-Mitte, Hanover

30189

RECRUITING

North Georgia Clinical Research, Woodstock

30449

NOT_YET_RECRUITING

Siteworks GmbH - Hannover, Hanover

31000

NOT_YET_RECRUITING

Investigacion y Biomedicina de Chihuahua, Chihuahua City

37909

RECRUITING

AMR Clinical, Knoxville

39008

NOT_YET_RECRUITING

Hospital Universitario Marqués de Valdecilla, Santander

41003

NOT_YET_RECRUITING

Clínica nuevas Tecnologías en Diabetes y Endocrinología (NTDE), Seville

41010

NOT_YET_RECRUITING

Hospital Quiron Infanta Luisa, Seville

44787

NOT_YET_RECRUITING

Siteworks GmbH - Bochum, Bochum

47010

NOT_YET_RECRUITING

Hospital Clínico Universitario de Valladolid, Valladolid

57701

NOT_YET_RECRUITING

Care Access - Rapid City, Rapid City

60611

RECRUITING

Northwestern University, Chicago

63065

NOT_YET_RECRUITING

Dedicated Research Site FutureMeds, Offenbach

63303

NOT_YET_RECRUITING

StudyMetrix Research, City of Saint Peters

64020

NOT_YET_RECRUITING

IMED Internal Medicine Clin Trials, Monterrey

64114

RECRUITING

AMR Clinical, Kansas City

64610

NOT_YET_RECRUITING

Clínica García Flores SC, Monterrey

67114

RECRUITING

AMR Clinical, Newton

69115

NOT_YET_RECRUITING

Siteworks GmbH - Heidelberg, Heidelberg

75208

RECRUITING

Mercy Family Clinic, Dallas

76137

NOT_YET_RECRUITING

Klinische Forschung Karlsruhe, Karlsruhe

77040

NOT_YET_RECRUITING

Juno Research, Houston

77084

NOT_YET_RECRUITING

Biopharma Informatic, LLC, Houston

77339

RECRUITING

Activian Clinical Research, Kingwood

77382

NOT_YET_RECRUITING

Advanced Rheumatology of Houston - Woodlands, The Woodlands

80809

NOT_YET_RECRUITING

CDG Studienambulanz Hartard, München

80909

NOT_YET_RECRUITING

Legacy Clinical Trials, Colorado Springs

85053

NOT_YET_RECRUITING

Arizona Research Center, Phoenix

85281

RECRUITING

AMR Clinical, Tempe

89440

NOT_YET_RECRUITING

Centro de Estudios de Investigacion Metabolicos y Cardiovasculares, S.C., Ciudad Madero

91360

NOT_YET_RECRUITING

Care Access - Thousand Oaks, Thousand Oaks

92648

NOT_YET_RECRUITING

Care Access - Huntington Beach, Huntington Beach

97070

NOT_YET_RECRUITING

Kohler & Milstein Research S.A. De C.V., Mérida

97074

NOT_YET_RECRUITING

Universitaetsklinikum Wuerzburg, Würzburg

98007

RECRUITING

Northwest Clinical Research Center, Bellevue

100053

NOT_YET_RECRUITING

Xuanwu Hospital Capital Medical University, Beijing

110002

NOT_YET_RECRUITING

Maulana Azad Medical College and Associated with Lok Nayak Hospital, New Delhi

150001

NOT_YET_RECRUITING

The Fourth Affiliated Hospital of Harbin Medical University, Harbin

200040

NOT_YET_RECRUITING

Huashan Hospital, Fudan University, Shanghai

208011

NOT_YET_RECRUITING

Atmaram Child Care, Kanpur

210029

NOT_YET_RECRUITING

Jiangsu Province Hospital, Nanjing

230011

NOT_YET_RECRUITING

The Second People's Hospital of Hefei, Hefei

250013

NOT_YET_RECRUITING

Jinan Central Hospital, Jinan

337055

NOT_YET_RECRUITING

Pingxiang People's Hospital, Pingxiang

400010

NOT_YET_RECRUITING

The Second Affiliated Hospital Chongqing Medical University, Chongqing

411027

NOT_YET_RECRUITING

Vencer Hospital, Pimpri-Chinchwad

440001

NOT_YET_RECRUITING

Kims Kingsway Hospital, Nagpur

471003

NOT_YET_RECRUITING

The First Affiliated Hospital of Henan University of Science &Technology, Luoyang

515041

NOT_YET_RECRUITING

The First Affiliated Hospital of Shantou University Medical College, Shantou

518053

NOT_YET_RECRUITING

The University of Hong Kong-Shenzhen Hospital, Shenzhen

600003

NOT_YET_RECRUITING

Rajiv Gandhi Government General Hospital, Chennai

751019

NOT_YET_RECRUITING

All India Institute of Medical Sciences, Bhubaneswar

06708

RECRUITING

Chase Medical Research, LLC, Waterbury

02451

NOT_YET_RECRUITING

MedVadis Research Corporation, Waltham

08873

NOT_YET_RECRUITING

Cardio Metabolic Institute, Somerset

L6T 0G1

NOT_YET_RECRUITING

Aggarwal and Associates Limited, Brampton

L8J 0B6

NOT_YET_RECRUITING

Winterberry Research Inc., Hamilton

J6E 6A9

NOT_YET_RECRUITING

Diex Recherche Joliette, Joliette

L2H 1H5

NOT_YET_RECRUITING

Your Research Network, Niagara Falls

G1V 3M7

NOT_YET_RECRUITING

G.R.M.O. (Groupe de recherche en maladies osseuses) Inc., Québec

G2J 0C4

NOT_YET_RECRUITING

Alpha Recherche Clinique, Québec

G3K 2P8

NOT_YET_RECRUITING

ALPHA Recherche Clinique, Québec

N7T 4X3

NOT_YET_RECRUITING

Bluewater Clinical Research Group Inc., Sarnia

V8V 4A1

NOT_YET_RECRUITING

Dr. M.B. Jones Inc., Victoria

014010

NOT_YET_RECRUITING

The First Affiliated Hospital of Baotou Medical College, Inner Mongolia University of Science and Technolo -T, Baotou

01069

NOT_YET_RECRUITING

Klinische Forschung Dresden, Dresden

04107

NOT_YET_RECRUITING

AmBeNet GmbH, Leipzig

810-8539

NOT_YET_RECRUITING

Hamanomachi Hospital, Fukuoka

811-0213

NOT_YET_RECRUITING

Fukuoka Wajiro Hospital, Fukuoka

693-8501

NOT_YET_RECRUITING

Shimane University Hospital, Izumo

213-0001

NOT_YET_RECRUITING

Ando Orthopedic, Kawasaki

108-0073

NOT_YET_RECRUITING

Tokyo Saiseikai Central Hospital, Minatoku

880-0835

NOT_YET_RECRUITING

Goto Orthopedic Surgery Clinic, Miyazaki

020-0021

NOT_YET_RECRUITING

Kato Orthopedic Clinic, Morioka

330-0074

NOT_YET_RECRUITING

Japan Community Health Care Organization - Saitama Medical Center, Saitama

060-0007

NOT_YET_RECRUITING

Sapporo Maruyama Orthopedic Hospital, Sapporo

167-0051

NOT_YET_RECRUITING

Masumoto Orthopedics Clinic, Suginami City

08035

NOT_YET_RECRUITING

Hospital Universitari Vall d'Hebron, Barcelona

All Listed Sponsors
lead

Eli Lilly and Company

INDUSTRY

NCT07153471 - A Study of Orforglipron (LY3502970) in Participants With Obesity or Overweight and Osteoarthritis (OA) of the Knee | Biotech Hunter | Biotech Hunter