150
Participants
Start Date
March 28, 2025
Primary Completion Date
December 31, 2029
Study Completion Date
June 30, 2030
olverembatinib
"All Ph+-ALL patients will uniformly use the 3rd generation of TKI olverembatinib (OVB) instead of dasatinib throughout the regimen.~OVB is combined with Vincristine and Prednisone (VP) during the first 2 weeks and with blinatumomab during the last 4 weeks of remission induction in this protocol.~Patients will receive blinatumomab for 28 days as induction instead of CAT to improve induction response and avoid toxicity.~All patients will receive two cycles of HDMTX+Blina-14 and 4 times of triple intrathecal therapy (TIT) throughout the consolidation 1 phase.~To decrease the toxicities of high-dose AraC, the dosage will be reduced to 1 g/m2 in the consolidation 2 phase in contrast to 2 g/m2 in 2020 protocol.~Throughout the early Maintenance Therapy, dexamethasone and vincristine combination will be added with either venetoclax or daunorubicin alternatively for five cycles, given after MTX and 6-MP."
NOT_YET_RECRUITING
Anhui Medical University Second Affiliated Hospita, Hefei
NOT_YET_RECRUITING
Chongqing Medical University Affiliated Children's Hospital, Chongqing
NOT_YET_RECRUITING
Fujian Medical University Union Hospital, Fuzhou
NOT_YET_RECRUITING
Guangzhou Women and Children's Medical Center, Guangzhou
NOT_YET_RECRUITING
Nanfang Hospital, Southern Medical University, Guangzhou
NOT_YET_RECRUITING
The First Affiliated Hospital, Sun Yat-sen University, Guangzhou
NOT_YET_RECRUITING
The Affiliated Hospital of Guizhou Medical University, Guiyang
NOT_YET_RECRUITING
Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan
NOT_YET_RECRUITING
Union Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan
NOT_YET_RECRUITING
Wuhan Children's Hospital, Wuhan
NOT_YET_RECRUITING
Hunan Children's Hospital, Changsha
NOT_YET_RECRUITING
The Third Xiangya Hospital of the Central South University, Changsha
NOT_YET_RECRUITING
Nanjing Children's Hospital Affiliated to Nanjing Medical University, Nanjin
NOT_YET_RECRUITING
Children's Hospital of Soochow University, Suzhou
NOT_YET_RECRUITING
Jiangxi Provincial Children's Hospital, Nanchang
NOT_YET_RECRUITING
Qilu Hospital of Shandong University, Jinan
NOT_YET_RECRUITING
Affiliated Hospital of Qingdao University, Qingdao
NOT_YET_RECRUITING
Children's Hospital of Fudan University, Shanghai
NOT_YET_RECRUITING
Shanghai Children's Hospital, Shanghai
NOT_YET_RECRUITING
Shenzhen Children's Hospital, Shenzhen
NOT_YET_RECRUITING
West China Second University Hospita, Chengdu
RECRUITING
Institute of Hematology and Blood Diseases Hospital, CAMS & PUMC, Tianjin
NOT_YET_RECRUITING
Institute of Hematology and Blood Diseases Hospital, CAMS & PUMC, Tianjin
NOT_YET_RECRUITING
Hong Kong Children's Hospital, The Chinese University of Hong Kong, Hong Kong
Institute of Hematology & Blood Diseases Hospital, China
OTHER