74
Participants
Start Date
December 31, 2025
Primary Completion Date
February 28, 2028
Study Completion Date
October 31, 2028
Oxaliplatin intravenous
85 mg/m² IV over 2 hours ; 1 cycle each 15 days
5 FU bolus
5 fluorouracil : 400 mg/m² in bolus of 10 minutes (intravenous)
Folinic acid
400 mg/m² in intravenous
5 FU continuous
2400 mg/m² intravenously over 46 hours
Irinotecan
180 mg/m² IV over 1h30
FRUQUINTINIB
5 mg capsule, taken orally, once daily for 3 weeks, followed by a 7-day break, then resumed (Day 1= Day 29).
BEVACIZUMAB
5 mg/kg over 90 minutes for the 1st course and in case of good tolerance the 2nd course should be administered over 60 minutes. The next courses should be administered in 30 minutes in case of good tolerance during the 2nd course
ICO Site Paul Papin, Angers
Les Bonnettes, Arras
Ght Unyon Auxerre, Auxerre
Bayeux Ch, Bayeux
Cote Basque, Bayonne
Beauvais Ch, Beauvais
Jean Minjoz, Besançon
Centre Pierre Curie, Beuvry
BERGONIÉ, Bordeaux
TIVOLI, Bordeaux
Chauny Ch, Chauny
Cholet Ch, Cholet
Saint Côme, Compiègne
Clinique de Flandre, Coudekerque-Branche
GHPSO Site de Creil, Creil
Centre Leonard de Vinci, Dechy
Dijon Bourgogne, Dijon
Institut de cancérologie de Bourgogne GRReCC, Dijon
CHD Vendée, La Roche-sur-Yon
Docteur Schaffner, Lens
Franco Britannique, Levallois-Perret
Jean Mermoz, Lyon
La Timone, Marseille
LAYNÉ CH, Mont-de-Marsan
Centre de Cancérologie du Grand Montpellier, Montpellier
Confluent Sas, Nantes
Groupe Hospitalier Diaconesses Croix Saint Simon, Paris
Hôpital Européen G Pompidou, Paris
La Pitié Salpêtrière, Paris
Saint Louis, Paris
La Miletrie, Poitiers
Jean Godinot, Reims
Robert Debré, Reims
Saint Gregoire Chp, Saint-Grégoire
ICO Site René Gauducheau, Saint-Herblain
Clinique Mutualiste de L'Estuaire, Saint-Nazaire
Hopital Nord Chu Saint Etienne, Saint-Priest-en-Jarez
Saint Malo Ch, St-Malo
ICAN Institut de Cancérologie de Strasbourg Europe, Strasbourg
Sainte Anne, Strasbourg
LEMAN, Thonon-les-Bains
Valence Ch, Valence
BRABOIS, Vandœuvre-lès-Nancy
Ch Nord Ouest, Villefranche-sur-Saône
Gustave Roussy, Villejuif
Federation Francophone de Cancerologie Digestive
OTHER