Early Blood Pressure Intervention After Coiling or Clipping for Subarachnoid Hemorrhage

NANot yet recruitingINTERVENTIONAL
Enrollment

750

Participants

Timeline

Start Date

August 31, 2025

Primary Completion Date

July 31, 2028

Study Completion Date

July 31, 2028

Conditions
Aneurysmal Subarachnoid HemorrhageAneurysmal Subarachnoid Hemorrhage (aSAH)
Interventions
OTHER

Blood pressure was regulated within the normal target management range

Blood pressure monitoring was initiated immediately upon the patient's return to the intensive care unit (ICU) postoperatively, followed by randomization. Blood pressure management was guided by systolic blood pressure (SBP) measurements, with physicians encouraged to adjust therapy based on institutional protocols and clinical judgment. For SBP \<120 mmHg, intravenous crystalloid or colloid fluid resuscitation was prioritized. If the target blood pressure was not achieved, norepinephrine infusion was initiated at a minimum dose of 0.1 µg/kg/min and titrated up to a maximum of 0.5 µg/kg/min to maintain SBP between 120-160 mmHg (\<160 mmHg and \>120 mmHg). For SBP \>160 mmHg, intravenous or oral antihypertensive drugs were administered to reduce and maintain SBP within the 120-160 mmHg range. For SBP within the range of 120-160 mmHg, standard supportive care was provided.

OTHER

Blood pressure was regulated within the elevated target management range

Blood pressure monitoring was initiated immediately upon the patient's return to the intensive care unit (ICU) postoperatively, followed by randomization. Blood pressure management was guided by systolic blood pressure (SBP) measurements, with physicians encouraged to adjust therapy based on institutional protocols and clinical judgment. For SBP \<160 mmHg, intravenous crystalloid or colloid fluid resuscitation was prioritized. If the target blood pressure was not achieved, norepinephrine infusion was initiated at a minimum dose of 0.1 µg/kg/min and titrated up to a maximum of 0.5 µg/kg/min to maintain SBP between 160-180 mmHg ( ≥160 mmHg and ≤120 mmHg). For SBP \>180 mmHg, intravenous or oral antihypertensive drugs were administered to reduce and maintain SBP within the 120-160 mmHg range. For SBP within the range of 160-180 mmHg, standard supportive care was provided.

Trial Locations (1)

107000

Beijing Tiantan Hospital, Capital Medical University, Beijing

All Listed Sponsors
collaborator

Development Center for Medical Science & Technology National Health Commission of the People's Republic of China

UNKNOWN

collaborator

Tianjin Medical University General Hospital

OTHER

lead

Beijing Tiantan Hospital

OTHER