Dexmedetomidine Dose-Dependent on Lung Function and AQP1 in One-Lung Ventilation Surgery

NACompletedINTERVENTIONAL
Enrollment

60

Participants

Timeline

Start Date

January 5, 2018

Primary Completion Date

March 29, 2019

Study Completion Date

March 29, 2019

Conditions
Acute Lung Injury(ALI)
Interventions
DRUG

dexmedetomidine 0.3 µg/kg/h

Following Anesthesia induction, dexmedetomidine (DEX) Low Dose group received a DEX loading dose (0.5 µg/kg over 10 min), followed by continuous infusions of 0.3 µg/kg/h, respectively, until 30 minutes before the end of the operation.

DRUG

dexmedetomidine 0.5 µg/kg/h

Following Anesthesia induction, dexmedetomidine (DEX) high dose group received a DEX loading dose (0.5 µg/kg over 10 min), followed by continuous infusions of 0.5 µg/kg/h, respectively, until 30 minutes before the end of the operation.

DRUG

0.9 % saline

Placebo group received an equivalent volume of 0.9% saline.

Trial Locations (1)

541002

Department of Anesthesiology, Nanxishan Hospital of Guangxi Zhuang Autonomous Region, Guilin

All Listed Sponsors
lead

People's Hospital of Guangxi Zhuang Autonomous Region

OTHER

NCT07145814 - Dexmedetomidine Dose-Dependent on Lung Function and AQP1 in One-Lung Ventilation Surgery | Biotech Hunter | Biotech Hunter