Effects of Early Rehabilitation Using Blood Flow Restriction and/or Surface Electromyography Biofeedback on Quadriceps Activation and Strength After Anterior Cruciate Ligament Reconstruction: A Multicenter Randomized Controlled Trial

NANot yet recruitingINTERVENTIONAL
Enrollment

200

Participants

Timeline

Start Date

January 2, 2026

Primary Completion Date

April 2, 2026

Study Completion Date

January 2, 2031

Conditions
Anterior Cruciate Ligament InjuriesKnee InjuriesMuscle Weakness
Interventions
BEHAVIORAL

Standard Rehabilitation

Standardized postoperative ACL rehabilitation only. Begins \~2 weeks after surgery; supervised \~3 sessions/week for 6 weeks. Includes progressive range of motion, quadriceps activation/strengthening, functional drills, and return-to-activity progressions delivered per protocol.

BEHAVIORAL

Blood Flow Restriction (BFR) Training

Low-load resistance exercises performed with individualized limb occlusion pressure (LOP) determined each session; target %LOP per protocol. Progresses from isometric to dynamic open/closed-chain tasks. Delivered under supervision \~3 sessions/week for 6 weeks; monitoring of tolerance and adverse events per safety LOP.

BEHAVIORAL

sEMG Biofeedback

Real-time surface electromyography biofeedback to optimize quadriceps recruitment during targeted tasks (e.g., isometric contractions, straight-leg raise, sit-to-stand, mini-squat, gait drills). Visual and/or auditory feedback with progressive targets. Supervised \~3 sessions/week for 6 weeks; outcome assessors remain blinded.

Trial Locations (4)

Unknown

Orthosport, Domont

Movare, Bulle

Centre de l'Appareil Locomoteur et du Sport, Hôpitaux Universitaires de Genève (HUG), Geneva

Exotherapie, Geneva

All Listed Sponsors
lead

Haute Ecole ARC Sante

OTHER

NCT07145606 - Effects of Early Rehabilitation Using Blood Flow Restriction and/or Surface Electromyography Biofeedback on Quadriceps Activation and Strength After Anterior Cruciate Ligament Reconstruction: A Multicenter Randomized Controlled Trial | Biotech Hunter | Biotech Hunter