NCT07144384View on ClinicalTrials.gov

Intratumoral Injection of Standard Universal Donor Expanded Natural Killer Cells and TGF-beta Imprinted Natural Killer Cells for the Treatment of Skin Squamous Cell Carcinoma and Basal Cell Carcinoma

EARLY_PHASE1Not yet recruitingINTERVENTIONAL
Enrollment

40

Participants

Timeline

Start Date

October 1, 2025

Primary Completion Date

December 31, 2026

Study Completion Date

December 31, 2026

Conditions
Skin Basal Cell CarcinomaSkin Nodular Basal Cell CarcinomaSkin Squamous Cell Carcinoma
Interventions
PROCEDURE

Biopsy Procedure

Undergo SOC biopsy

BIOLOGICAL

Natural Killer Cell Therapy

Given UD expanded NK cells intratumorally

PROCEDURE

Surgical Procedure

Undergo SOC excision

BIOLOGICAL

Universal Donor Expanded TGF-beta-imprinted NK Cells

Given intratumorally

Trial Locations (1)

43210

Ohio State University Comprehensive Cancer Center, Columbus

All Listed Sponsors
lead

Brittany Dulmage

OTHER