The Effect of Bacterial Decolonization Before Skin Cancer Surgery on Infection Rate of Lower Extremity Wounds Left Open to Heal

PHASE3RecruitingINTERVENTIONAL
Enrollment

848

Participants

Timeline

Start Date

March 13, 2023

Primary Completion Date

October 31, 2030

Study Completion Date

December 31, 2030

Conditions
Surgical Wound Infection
Interventions
DRUG

Chlorhexidine gluconate (4%)

Chlorhexidine 4% solution will be applied from the neck down (avoiding the face, penis, and vagina), allowed to sit on the skin for one minute, then rinsed off in the shower every day for 5 days prior to surgery.

DRUG

Mupirocin 2% Ointment

Mupirocin 2% ointment will be applied to the inside of the nostrils twice daily, in the morning and evening, for 5 days prior to surgery. A small amount of the ointment will be placed on the tip of a cotton swab to facilitate application to each nostril.

Trial Locations (1)

08053

RECRUITING

The Center for Dermatologic Surgery at Cooper University Health Care, Marlton

All Listed Sponsors
collaborator

University of California, Davis

OTHER

collaborator

Washington University School of Medicine

OTHER

collaborator

Baylor College of Medicine

OTHER

collaborator

Princeton Healthcare System

OTHER

collaborator

The Cleveland Clinic

OTHER

collaborator

University of Georgia

OTHER

collaborator

St. Luke's Hospital and Health Network, Pennsylvania

OTHER

lead

The Cooper Health System

OTHER