Primary Radiotherapy In MEtastatic Lung Cancer

PHASE3Not yet recruitingINTERVENTIONAL
Enrollment

420

Participants

Timeline

Start Date

January 1, 2026

Primary Completion Date

January 1, 2029

Study Completion Date

January 1, 2033

Conditions
Carcinoma, Non-Small-Cell Lung (NSCLC)
Interventions
COMBINATION_PRODUCT

Radiotherapy followed by chemotherapy

"Standard of care (SoC) regimens available on the Australian PBS or relevant practice framework (Ireland and Canada) as per usual standard clinical practice are allowable in this protocol as SoC regimens.~Radiotherapy Techniques:~* Highly conformal techniques (IMRT/VMAT)~* High-precision techniques are allowed for non-centrally located primaries~Radiotherapy Dose:~\- Several fractionation schedules allowed; minimum biological effective dose approximating 50Gy (α/β ratio = 10); 50Gy in 20 fractions, 40Gy in 15 fractions, and 35Gy in 5 fractions"

DRUG

Standard of Care (SOC)

Standard of care (SoC) regimens available on the Australian PBS or relevant practice framework (Ireland and Canada) as per usual standard clinical practice are allowable in this protocol as SoC regimens.

All Listed Sponsors
collaborator

Thoracic Oncology Group of Australasia (TOGA)

UNKNOWN

lead

Trans Tasman Radiation Oncology Group

OTHER