24
Participants
Start Date
September 1, 2025
Primary Completion Date
December 1, 2026
Study Completion Date
December 1, 2026
Dietary Supplement: Inorganic Nitrate (Beetroot juice)
Participants will be supplemented with inorganic nitrate in the form of beetroot juice for 4 days (12.9 mmol of NO3/day), and their vascular health, insulin sensitivity, and exercise capacity will be measured post-supplementation. This is a randomized crossover design with 2 parallel groups (Group 1: Currently taking metformin, Group 2: Naive to metformin).
Dietary supplement: Placebo (Nitrate-depleted beetroot juice)
Participants will be supplemented with nitrate-depleted beetroot juice for 4 days (\<0.01 mmol NO3/day), and their vascular health, insulin sensitivity, and exercise capacity will be measured post-supplementation. This is a randomized crossover design with 2 parallel groups (Group 1: Currently taking metformin, Group 2: Naive to metformin).
University of Virginia
OTHER