Interaction Between Inorganic Nitrate Supplementation and Metformin in Individuals With Prediabetes

NANot yet recruitingINTERVENTIONAL
Enrollment

24

Participants

Timeline

Start Date

September 1, 2025

Primary Completion Date

December 1, 2026

Study Completion Date

December 1, 2026

Conditions
MalesFemalesSedentaryMetforminPrediabetes
Interventions
DIETARY_SUPPLEMENT

Dietary Supplement: Inorganic Nitrate (Beetroot juice)

Participants will be supplemented with inorganic nitrate in the form of beetroot juice for 4 days (12.9 mmol of NO3/day), and their vascular health, insulin sensitivity, and exercise capacity will be measured post-supplementation. This is a randomized crossover design with 2 parallel groups (Group 1: Currently taking metformin, Group 2: Naive to metformin).

DIETARY_SUPPLEMENT

Dietary supplement: Placebo (Nitrate-depleted beetroot juice)

Participants will be supplemented with nitrate-depleted beetroot juice for 4 days (\<0.01 mmol NO3/day), and their vascular health, insulin sensitivity, and exercise capacity will be measured post-supplementation. This is a randomized crossover design with 2 parallel groups (Group 1: Currently taking metformin, Group 2: Naive to metformin).

All Listed Sponsors
lead

University of Virginia

OTHER