The Effect of Esketamine Combined With Dexmedetomidine on Postoperative Recovery Quality in Patients Undergoing Thoracoscopic Surgery

NAEnrolling by invitationINTERVENTIONAL
Enrollment

120

Participants

Timeline

Start Date

May 1, 2025

Primary Completion Date

March 1, 2026

Study Completion Date

April 1, 2026

Conditions
Esketamine Plus Dexmedetomidine Affect Postoperative QualityThoracoscopyLung Neoplasms
Interventions
DRUG

Saline Solution (NaCl 0,9%)

Administer 0.5 ug/kg of dexmedetomidine 10 minutes before surgery, and maintain at 0.4 ug/kg/h after intubation until 30 minutes before the end of surgery,Administer saline solution one minute after induction of anesthesia and continue until 30 minutes before the end of surgery.

DRUG

Low-dose esketamine infusion

Administer 0.5 ug/kg of dexmedetomidine 10 minutes before surgery, and maintain at 0.4 ug/kg/h after intubation until 30 minutes before the end of surgery, administer esketamine 0.2 mg/kg 1 minute after induction of anesthesia, maintain at 2 μg/kg/min after intubation until 30 minutes before the end of surgery.

DRUG

High-dose esketamine infusion

Administer 0.5 ug/kg of dexmedetomidine 10 minutes before surgery, and maintain at 0.4 ug/kg/h after intubation until 30 minutes before the end of surgery, Administer 0.2 mg/kg of esketamine 1 minute after induction of anesthesia, and maintain at 4 μg/kg/min after intubation until 30 minutes before the end of surgery.

Trial Locations (1)

6500000

First Affiliated Hospital of Kunming Medical University, Kunming

All Listed Sponsors
lead

First Affiliated Hospital of Kunming Medical University

OTHER