300
Participants
Start Date
August 31, 2025
Primary Completion Date
June 30, 2030
Study Completion Date
December 30, 2030
Administration of experimental treatment association (sotorasib, panitumumab 5FU)
Panitumumab is administered at a dose of 6 mg/kg via intravenous infusion over one hour during the first cycle, and over 30 minutes from the second cycle onward. The LV5FU2 regimen includes folinic acid (400 mg/m², or 200 mg/m² if levo-leucovorin is used) as a two-hour IV infusion, followed by a 5-FU bolus (400 mg/m² over 10 minutes), and a continuous 5-FU infusion (2400 mg/m² over 46 hours). Sotorasib is given orally at a dose of 960 mg once daily on a continuous basis.
ICO site Paul Papin, Angers
Centre Hospitalier Annecy Genevois, Annecy
Hôpital Privé, Antony
Centre Hospitalier, Aurillac
Centre Hospitalier, Bayeux
Ch Cote Basque, Bayonne
Ch Simone Veille, Beauvais
Chu Jean Minjoz, Besançon
Polyclinique Courlancy, Bezannes
Centre Hospitalier Béthune Beuvry, Béthune
Bordeaux Nord Aquitaine, Bordeaux
TIVOLI, Bordeaux
Chu Morvan, Brest
CHU Côte de Nacre, Caen
Centre Hospitalier, Cholet
Hôpitaux civils, Colmar
Polyclinique Saint-Côme, Compiègne
Chu Francois Mitterand, Dijon
Gf Leclerc, Dijon
Institut de cancérologie de Bourgogne GRReCC, Dijon
Groupe Hospitalier Mutualiste, Grenoble
Chd Vendee, La Roche-sur-Yon
Hôpital Franco Britannique, Levallois-Perret
Hôpital Privé Le Bois, Lille
CHU Dupuytren, Limoges
Groupe Hospitalier Bretagne Sud, Lorient
Hôpital Jean Mermoz, Lyon
Chu La Timone, Marseille
Hôpital Européen, Marseille
CHRU, Nancy
Gh Nord Essone, Orsay
Chu Cochin, Paris
HEGP, Paris
Montsouris, Paris
Saint-Louis, Paris
Centre Hospitalier, Pau
CHU Haut Leveque, Pessac
Centre Cario, Plérin
Chu La Miletrie, Poitiers
CH Quimper Concarneau, Quimper
Cac Jean Godinot, Reims
Chu Robert Debré, Reims
Centre Hospitalier, Saint-Denis
Hôpital Privé, Saint-Grégoire
Hia Begin, Saint-Mandé
Groupe Hospitalier Rance Emeraude, St-Malo
Clinique Sainte-Anne, Strasbourg
ICANS, Strasbourg
CHRU Trousseau, Tours
Hôpital Nord Ouest, Villefranche-sur-Saône
Saint Joseph Hospital Bochum, Bochum
Krankenhaus Nordwest-CH Frankfurt Am Main, Frankfurt
Universitätsmedizin Göttingen CHU, Göttingen
Hämatologisch Onkologische Praxis Eppendorf, Hamburg
Centro Di Riferimento Oncologico Di Aviano, Aviano
Azienda Ospedaliero Universitaria Policlinico Rodolico San Marco Di Catania, Catania
Azienda Ospedaliero Universitaria Careggi, Florence
Azienda Unita Sanitaria Locale 6 Livorno, Livorno
Istituto Romagnolo Per Lo Studio Dei Tumori Dino Amadori, Meldola
Fondazione IRCCS Istituto Nazionale Dei Tumori, Milan
Azienda Ospedaliero-Universitatia Di Cagliari, Monserrato
Istituto Oncologico Veneto, Padua
Azienda Ospedaliero-Universitaria Pisana, Pisa
Azienda USL Toscana Centro, Prato
Azienda Unita Sanitaria Locale Della Romagna, Ravenna
Azienda Ospedaliera Policlinico Universitario Tor Vergata, Roma
Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Roma
Casa Sollievo Della Sofferenza, San Giovanni Rotondo
Azienda Ospedaliero-Universitaria Città della salute e della scienza di Torino Presidio Molinette, Torino
Pia Fondazione Di Culto E Religione Card Panico, Tricase
Azienda Sanitaria Universitaria Friuli Centrale, Udine
Hospital Universitari Vall d'Hebron, Barcelona
Hospital Universitario Reina Sofia, Córdoba
Instituto Catalan de Oncologia. Hospital Duran i Reynals, L'Hospitalet de Llobregat
Hospital Universitario Gregorio Maranon, Madrid
Hospital Universitario Central de Asturias, Oviedo
Hospital Universitario de Navarra, Pamplona
Hospital Clinico Universitario de Salamanca, Salamanca
Hospital Universitario Clinico San Carlos, San Carlos
Consorcio Hospital General Universitario de Valencia, Valencia
Northwest Oncology Cooperative Group(GONO)
UNKNOWN
Arbeitsgemeinschaft fur Internistische Onkologie
OTHER
Spanish Cooperative Group for the Treatment of Digestive Tumours (TTD)
OTHER
Federation Francophone de Cancerologie Digestive
OTHER