Short-Term Effects of Sucralose and Saccharin on Blood Sugar and Gut Microbiota in Type 2 Diabetes

NANot yet recruitingINTERVENTIONAL
Enrollment

33

Participants

Timeline

Start Date

November 30, 2025

Primary Completion Date

May 30, 2026

Study Completion Date

July 31, 2026

Conditions
Type 2 Diabetes Mellitus (T2DM)
Interventions
DIETARY_SUPPLEMENT

Sucralose

Participants will consume one capsule containing sucralose 5mg/kg body weight, with the dosage individualized according to body weight. The capsule will be taken once daily in the morning, after breakfast, with plain water. This intervention will last for seven consecutive days.

DIETARY_SUPPLEMENT

Saccharin

Participants will consume one capsule containing saccharin 2mg/kg body weight, with the dosage individualized according to body weight. The capsule will be taken once daily in the morning, after breakfast, with plain water. This intervention will last for seven consecutive days.

OTHER

Placebo (Calcium Carbonate)

Participants will consume one capsule per day, containing a fixed dose of 500 mg. The capsule will be taken once daily in the morning, after breakfast, with plain water. This intervention will last for seven consecutive days.

Trial Locations (1)

53300

Klinik Kesihatan Setapak, Kuala Lumpur

All Listed Sponsors
collaborator

Monash University Malaysia

OTHER

lead

National University of Malaysia

OTHER