Efficacy and Safety of Keverprazan-amoxicillin Dual Therapy for Helicobacter Pylori First-line Treatment

PHASE4RecruitingINTERVENTIONAL
Enrollment

414

Participants

Timeline

Start Date

February 19, 2024

Primary Completion Date

August 31, 2025

Study Completion Date

December 30, 2025

Conditions
Helicobacter Pylori
Interventions
DRUG

Keverprazan 10 days

"Keverprazan dual therapy for 10 days (K10 group):~Keverprazan 20 mg per dose, twice daily (bid) + Amoxicillin 1 g per dose, three times (tid) daily, for 10 days."

DRUG

Keverprazan 14 days

Keverprazan dual therapy for 14 days (K14 group): Keverprazan 20 mg, bid + Amoxicillin 1 g, tid, for 14 days.

DRUG

Rabeprazole

Rabeprazole quadruple therapy for 14 days (R14 group): Rabeprazole sodium 10 mg + Amoxicillin 1 g + Clarithromycin 500 mg + Colloidal pectin bismuth 200 mg, bid, for 14 days.

Trial Locations (1)

310009

RECRUITING

The Second Affiliated Hospital Zhejiang University School of Medicine, Hangzhou

All Listed Sponsors
lead

Second Affiliated Hospital, School of Medicine, Zhejiang University

OTHER