Optimal Ventilation for Cardiac Arrest

NARecruitingINTERVENTIONAL
Enrollment

1,530

Participants

Timeline

Start Date

October 1, 2025

Primary Completion Date

March 31, 2030

Study Completion Date

March 31, 2030

Conditions
Cardiac Arrest (CA)
Interventions
OTHER

OPTI-VENT Bundle

"Provider Education: During a brief (\<2 minute) bedside education, the educator will 1) review the CPR ventilation rate targets for age, and 2) ensure the provider has a cue card of current rate recommendations on his/her person. Compliance will be defined as performance of at least 30 trainings per unit per month. We will record provider discipline and time since last training as a surrogate of training spread. Educators will leverage these two-minute trainings to review the patient's current ventilator settings as an initial target during CPR to ensure adequate chest rise.~Additionally, a focus on CPR ventilation rates will be integrated into resuscitation education or quality meetings for all disciplines. Report cards detailing unit-level performance will be generated by the study team for review during site monthly presentations.~Point-of-Care Guidance: A metronome will be deployed to all cardiac arrests using a smart phone application."

OTHER

Transition

There will be a 2-month transition period for study sites beginning study enrollment using standard ICU practices as they onboard to the study intervention.

OTHER

None - control

Control - no intervention

Trial Locations (20)

11040

RECRUITING

Cohen Children's Medical Center, New Hyde Park

19104

RECRUITING

Children's Hospital of Philadelphia, Philadelphia

19803

RECRUITING

Nemours Children's Health, Wilmington

23219

RECRUITING

Children's Hospital of Richmond at VCU, Richmond

27599

RECRUITING

UNC Children's Hospital, Chapel Hill

30303

RECRUITING

Children's Healthcare of Atlanta, Atlanta

43205

RECRUITING

Nationwide Children's Hospital, Columbus

45229

RECRUITING

Cincinnati Children's Hospital Medical Center, Cincinnati

46202

RECRUITING

Riley Children's Health, Indianapolis

52242

RECRUITING

Stead Family Children's Hospital, Iowa City

53226

RECRUITING

Children's Wisconsin, Milwaukee

63110

RECRUITING

Washington University in St. Louis, St Louis

75230

RECRUITING

Medical City Children's Hospital, Dallas

75390

RECRUITING

UT Southwestern Medical Center, Dallas

78723

RECRUITING

Dell Children's Medical Center, Austin

80045

RECRUITING

Children's Hospital Colorado, Denver

92868

RECRUITING

CHOC, Orange

94304

RECRUITING

Lucile Packard Children's Hospital Stanford, Palo Alto

98105

RECRUITING

Seattle Children's, Seattle

02115

RECRUITING

Boston Children's Hospital, Boston

All Listed Sponsors
collaborator

Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)

NIH

collaborator

University of Utah

OTHER

collaborator

Villanova University

OTHER

lead

Children's Hospital of Philadelphia

OTHER

NCT07114510 - Optimal Ventilation for Cardiac Arrest | Biotech Hunter | Biotech Hunter