Vibroacoustic Therapy With Oscillating Positive Expiratory Pressure in the Treatment of Nasal Congestion

NANot yet recruitingINTERVENTIONAL
Enrollment

200

Participants

Timeline

Start Date

August 31, 2025

Primary Completion Date

March 31, 2026

Study Completion Date

May 31, 2026

Conditions
Atopic RhinitisAtopic Asthma
Interventions
DEVICE

VPAT (Vibratory Positive Pressure Therapeutic Apparatus)

"VPAT (Vibratory Positive Pressure Therapeutic Apparatus)is a physical solution which can relieve nasal congestion and discomforts by applying acoustic vibration and oscillatory positive expiratory pressure. Clinical research has shown that low-frequency vibration at approximately 130 Hz promotes the production of the highest concentration of Nitric Oxide (NO) in the paranal sinuses, which helps to regulate the nasal mucosal blood, restoring the mucous membrance-cilia mechanism, clean up the bacteria, viruses and allergenic particles in the respiratory tract.~Combined with Oscillatory Positive Expiratory Pressure and Transnasal Breathing, it can help to cultivate the habit of nasal breathing and slow breathing, as well as to restore the function of lungs."

DRUG

basic medications (antihistamines, mometasone furoate nasal spray, ICS-LABA

"All participants need basic control drugs contains antihistamines(Ebastine 10 mg once daily for 2 weeks), mometasone furoate nasal spray(Spray 2 puffs into each nostril, each puff contains 50 μg of mometasone furoate, i.e., 100 μg per administration, once daily for 2 weeks).~Asthma participants should added Inhaled corticosteroids-long-acting beta-agonists (ICS-LABA) therapy. For mild to moderate asthma: budesonide/formoterol (160μg/4.5μg) , with 1 inhalation each time, twice daily, or salmeterol/fluticasone propionate (50μg/100μg) with 1 inhalation each time, twice daily. For moderate to severe asthma: Budesonide/Formoterol (320μg/4.5μg), with 1 inhalation each time, twice daily; or salmeterol/fluticasone propionate (50μg/250μg or 50μg/500μg) with 1 inhalation each time, twice daily. Dosage adjustments should be evaluated and determined by the physician based on the patient's disease control status."

DEVICE

OPEP(Oscillating Positive Expiratory Pressure device)

Oscillating Positive Expiratory Pressure (OPEP) device contain a inner ball that creates a resistance and oscillates when the patient blows through the device. This resistance helps splint the airways open during exhalation whilst the oscillation loosens the mucous within the airways. This makes it easier for some patients to clear their sputum.

Trial Locations (1)

310009

Huiying Wang, Hangzhou

All Listed Sponsors
collaborator

Huzhou Central Hospital

OTHER

collaborator

The Children's Hospital of Zhejiang University School of Medicine

OTHER

collaborator

First People's Hospital of Hangzhou

OTHER

lead

Second Affiliated Hospital, School of Medicine, Zhejiang University

OTHER

NCT07114107 - Vibroacoustic Therapy With Oscillating Positive Expiratory Pressure in the Treatment of Nasal Congestion | Biotech Hunter | Biotech Hunter