Phase 2/3 Trial of Izalontamab Brengitecan vs Platinum-based Chemotherapy for Metastatic Urothelial Cancer With Disease Progression on or After Immunotherapy

PHASE2/PHASE3RecruitingINTERVENTIONAL
Enrollment

470

Participants

Timeline

Start Date

September 30, 2025

Primary Completion Date

January 26, 2029

Study Completion Date

November 18, 2033

Conditions
Urothelial Cancer
Interventions
DRUG

Iza-bren

Specified dose on specified days

DRUG

Cisplatin

Specified dose on specified days

DRUG

Gemcitabine

Specified dose on specified days

DRUG

Carboplatin

Specified dose on specified days

Trial Locations (136)

1090

NOT_YET_RECRUITING

Local Institution - 0109, Vienna

1160

NOT_YET_RECRUITING

Local Institution - 0131, Vienna

1478

NOT_YET_RECRUITING

Local Institution - 0239, Lørenskog

1714

NOT_YET_RECRUITING

Local Institution - 0246, Sarpsborg

2065

NOT_YET_RECRUITING

Local Institution - 0151, St Leonards

2109

RECRUITING

Macquarie University, Macquarie University

2610

NOT_YET_RECRUITING

Local Institution - 0013, Wilrijk

3084

NOT_YET_RECRUITING

Local Institution - 0150, Heidelberg

3103

NOT_YET_RECRUITING

Local Institution - 0242, Tønsberg

4000

NOT_YET_RECRUITING

Local Institution - 0012, Liège

5000

NOT_YET_RECRUITING

Local Institution - 0025, Córdoba

6020

NOT_YET_RECRUITING

Local Institution - 0155, Innsbruck

6500

NOT_YET_RECRUITING

Local Institution - 0117, Bellinzona

7000

NOT_YET_RECRUITING

Local Institution - 0108, Chur

8091

NOT_YET_RECRUITING

Local Institution - 0148, Zurich

9000

NOT_YET_RECRUITING

Local Institution - 0011, Ghent

NOT_YET_RECRUITING

Local Institution - 0014, Ghent

9007

NOT_YET_RECRUITING

Local Institution - 0077, Sankt Gallen

10117

NOT_YET_RECRUITING

Local Institution - 0154, Berlin

13273

NOT_YET_RECRUITING

Local Institution - 0005, Marseille

16132

NOT_YET_RECRUITING

Local Institution - 0099, Genoa

17176

NOT_YET_RECRUITING

Local Institution - 0235, Stockholm

20132

NOT_YET_RECRUITING

Local Institution - 0105, Milan

20133

NOT_YET_RECRUITING

Local Institution - 0104, Milan

20246

NOT_YET_RECRUITING

Local Institution - 0134, Hamburg

21287

NOT_YET_RECRUITING

Local Institution - 0232, Baltimore

22903

NOT_YET_RECRUITING

Local Institution - 0158, Charlottesville

23502

NOT_YET_RECRUITING

Local Institution - 0188, Norfolk

24105

NOT_YET_RECRUITING

Local Institution - 0075, Kiel

30625

NOT_YET_RECRUITING

Local Institution - 0144, Hanover

33075

NOT_YET_RECRUITING

Local Institution - 0004, Bordeaux

33176

NOT_YET_RECRUITING

Local Institution - 0247, Miami

35128

NOT_YET_RECRUITING

Local Institution - 0103, Padua

37203

NOT_YET_RECRUITING

Local Institution - 0186, Nashville

37232

NOT_YET_RECRUITING

Local Institution - 0084, Nashville

40225

NOT_YET_RECRUITING

Local Institution - 0076, Düsseldorf

40536

NOT_YET_RECRUITING

Local Institution - 0193, Lexington

43126

NOT_YET_RECRUITING

Local Institution - 0098, Parma

43210

NOT_YET_RECRUITING

Local Institution - 0161, Columbus

44195

NOT_YET_RECRUITING

Local Institution - 0192, Cleveland

44625

NOT_YET_RECRUITING

Local Institution - 0078, Herne

44805

NOT_YET_RECRUITING

Local Institution - 0002, Saint-Herblain

46009

NOT_YET_RECRUITING

Local Institution - 0199, Valencia

48201

NOT_YET_RECRUITING

Local Institution - 0168, Detroit

56126

NOT_YET_RECRUITING

Local Institution - 0100, Pisa

60488

NOT_YET_RECRUITING

Local Institution - 0190, Frankfurt

63011

NOT_YET_RECRUITING

Local Institution - 0003, Clermont-Ferrand

67098

NOT_YET_RECRUITING

Local Institution - 0040, Strasbourg

69120

NOT_YET_RECRUITING

Local Institution - 0133, Heidelberg

69373

NOT_YET_RECRUITING

Local Institution - 0006, Lyon Cedex08

70124

NOT_YET_RECRUITING

Local Institution - 0097, Bari

70300

NOT_YET_RECRUITING

Local Institution - 0106, Ẕerifin

72622

NOT_YET_RECRUITING

Local Institution - 0080, Nürtingen

75014

NOT_YET_RECRUITING

Local Institution - 0007, Paris

75015

NOT_YET_RECRUITING

Local Institution - 0008, Paris

78705

NOT_YET_RECRUITING

Local Institution - 0187, Austin

80100

NOT_YET_RECRUITING

Local Institution - 0107, Naples

80435

WITHDRAWN

Local Institution - 0245, Dillon

81632

NOT_YET_RECRUITING

Local Institution - 0191, Edwards

81675

NOT_YET_RECRUITING

Local Institution - 0079, Munich

84107

NOT_YET_RECRUITING

Local Institution - 0111, Murray

85234

NOT_YET_RECRUITING

Local Institution - 0167, Gilbert

89081

NOT_YET_RECRUITING

Local Institution - 0132, Ulm

92151

NOT_YET_RECRUITING

Local Institution - 0223, Suresnes

92835

NOT_YET_RECRUITING

Local Institution - 0162, Fullerton

93053

NOT_YET_RECRUITING

Local Institution - 0135, Regensburg

94800

NOT_YET_RECRUITING

Local Institution - 0001, Villejuif

95816

NOT_YET_RECRUITING

Local Institution - 0163, Sacramento

95817

NOT_YET_RECRUITING

Local Institution - 0139, Sacramento

97239

NOT_YET_RECRUITING

Local Institution - 0141, Portland

98101

NOT_YET_RECRUITING

Local Institution - 0200, Seattle

100034

NOT_YET_RECRUITING

Local Institution - 0050, Beijing

100091

NOT_YET_RECRUITING

Local Institution - 0224, Beijing

200032

NOT_YET_RECRUITING

Local Institution - 0042, Shanghai

200542

NOT_YET_RECRUITING

Local Institution - 0067, Craiova

210000

NOT_YET_RECRUITING

Local Institution - 0044, Nanjing

210009

NOT_YET_RECRUITING

Local Institution - 0046, Nanjing

226361

NOT_YET_RECRUITING

Local Institution - 0114, Nantong

250117

NOT_YET_RECRUITING

Local Institution - 0184, Jinan

264000

NOT_YET_RECRUITING

Local Institution - 0205, Yantai

266003

NOT_YET_RECRUITING

Local Institution - 0156, Qingdao

300060

NOT_YET_RECRUITING

Local Institution - 0052, Tianjin

300070

NOT_YET_RECRUITING

Local Institution - 0227, Tianjin

310022

NOT_YET_RECRUITING

Local Institution - 0157, Hangzhou

325000

NOT_YET_RECRUITING

Local Institution - 0053, Wenzhou

330006

NOT_YET_RECRUITING

Local Institution - 0206, Nanchang

350001

NOT_YET_RECRUITING

Local Institution - 0048, Fuzhou

350005

NOT_YET_RECRUITING

Local Institution - 0060, Fuzhou

361003

NOT_YET_RECRUITING

Local Institution - 0056, Xiamen

400015

NOT_YET_RECRUITING

Local Institution - 0066, Cluj-Napoca

410013

NOT_YET_RECRUITING

Local Institution - 0059, Changsha

430030

NOT_YET_RECRUITING

Local Institution - 0201, Wuhan

450008

NOT_YET_RECRUITING

Local Institution - 0064, Zhengzhou

510060

NOT_YET_RECRUITING

Local Institution - 0051, Guangzhou

510120

NOT_YET_RECRUITING

Local Institution - 0058, Guangzhou

510280

NOT_YET_RECRUITING

Local Institution - 0226, Guangzhou

610066

NOT_YET_RECRUITING

Local Institution - 0225, Chengdu

700483

NOT_YET_RECRUITING

Local Institution - 0072, Iași

3109601

NOT_YET_RECRUITING

Local Institution - 0094, Haifa

4941492

NOT_YET_RECRUITING

Local Institution - 0096, Petah Tikva

9112001

NOT_YET_RECRUITING

Local Institution - 0095, Jerusalem

02215

NOT_YET_RECRUITING

Local Institution - 0195, Boston

CP1280AEB

NOT_YET_RECRUITING

Local Institution - 0028, CABA

C1426ANZ

NOT_YET_RECRUITING

Local Institution - 0023, Ciudad Autónoma de Buenos Aires

C1199ABB

NOT_YET_RECRUITING

Local Institution - 0024, ABB

C1419AHN

NOT_YET_RECRUITING

Local Institution - 0026, Buenos Aires

M5500AYB

NOT_YET_RECRUITING

Local Institution - 0027, Mendoza

41253-190

NOT_YET_RECRUITING

Local Institution - 0129, Salvador

90610-000

NOT_YET_RECRUITING

Local Institution - 0121, Porto Alegre

22451-100

NOT_YET_RECRUITING

Local Institution - 0130, Rio de Janeiro

01452-000

NOT_YET_RECRUITING

Local Institution - 0124, São Paulo

T6G 1Z2

NOT_YET_RECRUITING

Local Institution - 0020, Edmonton

K1H 8L6

NOT_YET_RECRUITING

Local Institution - 0021, Ottawa

M5G 2M9

NOT_YET_RECRUITING

Local Institution - 0016, Toronto

H4A 3J1

NOT_YET_RECRUITING

Local Institution - 0017, Montreal

500 05

NOT_YET_RECRUITING

Local Institution - 0146, Hradec Králové

150 06

NOT_YET_RECRUITING

Local Institution - 0041, Prague

06189

NOT_YET_RECRUITING

Local Institution - 0009, Nice

07747

NOT_YET_RECRUITING

Local Institution - 0147, Jena

T12 E8YV

NOT_YET_RECRUITING

Local Institution - 0238, Cork

D24 NR0A

NOT_YET_RECRUITING

Local Institution - 0236, Dublin

00144

NOT_YET_RECRUITING

Local Institution - 0102, Rome

216-8511

NOT_YET_RECRUITING

Local Institution - 0183, Kawasaki

113-8603

NOT_YET_RECRUITING

Local Institution - 0171, Bunkyo-ku

135-8550

NOT_YET_RECRUITING

Local Institution - 0169, Koto-ku

930-0194

NOT_YET_RECRUITING

Local Institution - 0179, Toyoma

4818 CK

NOT_YET_RECRUITING

Local Institution - 0036, Breda

1066 CX

NOT_YET_RECRUITING

Local Institution - 0033, Amsterdam

8934 AD

NOT_YET_RECRUITING

Local Institution - 0031, Leeuwarden

06006

NOT_YET_RECRUITING

Local Institution - 0216, Badajoz

413 45

NOT_YET_RECRUITING

Local Institution - 0234, Gothenburg

SE-221 85

NOT_YET_RECRUITING

Local Institution - 0241, Lund

G12 0YN

NOT_YET_RECRUITING

Local Institution - 0243, Glasgow

EC1A 7BE

NOT_YET_RECRUITING

Local Institution - 0237, London

S10 2SJ

NOT_YET_RECRUITING

Local Institution - 0230, Sheffield

SM2 5PT

NOT_YET_RECRUITING

Local Institution - 0231, Sutton

Sponsors
All Listed Sponsors
lead

Bristol-Myers Squibb

INDUSTRY

NCT07106762 - Phase 2/3 Trial of Izalontamab Brengitecan vs Platinum-based Chemotherapy for Metastatic Urothelial Cancer With Disease Progression on or After Immunotherapy | Biotech Hunter | Biotech Hunter