100
Participants
Start Date
March 25, 2025
Primary Completion Date
February 6, 2026
Study Completion Date
February 29, 2028
Ventriculoperitoneal Shunt (VP)
VP Shunt surgery involves surgical insertion of a catheter (tube) to divert brain fluid from the cerebral ventricles to the abdominal peritoneum. This will be performed in Group 1 patients as clinically indicated.
Brain and Skin Biopsy
Brain and skin biopsy's may be taken during the VP shunt to assist in histological analysis for neurodegenerative changes.
MRI Brain
MRI brain with diffusion imagining will be performed before and after shunt surgery.
RECRUITING
Imperial College Healthcare NHS Trust, London
Collaborators (1)
Medical Research Council
OTHER_GOV
Michael J. Fox Foundation for Parkinson's Research
OTHER
University College, London
OTHER
University of Edinburgh
OTHER
King's College London
OTHER
Imperial College London
OTHER