Effect of Local Use of Non-steroidal Anti-inflammatory Agent (Diclofenac Sodium) With and Without Hyaluronidase on Post-surgical Pain and Swelling

NANot yet recruitingINTERVENTIONAL
Enrollment

44

Participants

Timeline

Start Date

August 1, 2025

Primary Completion Date

August 1, 2025

Study Completion Date

August 8, 2025

Conditions
Root End ResectionPeriapical LesionSingle Rooted Teeth
Interventions
DRUG

Diclofenac Sodium Gel

I1: Diclofenac sodium : 1 mL of gel, of 1 mL of 3 mL/75 mg Diclofenac sodium and 1% Carbopol 940 gel base, will be passively placed in the osseous cavity I2: Hyaluronidase : 1 mL of gel, of 1 ampoule (1500 IU) Hyalase powder in 2.5 mL of 0.9% sodium chloride, and 1% Carbopol 940 gel base, will be passively placed in the osseous cavity I3: Diclofenac sodium and Hyaluronidase: 1 mL of gel, of 1 ampoule (1500 IU) Hyalase powder and 1 ampoule (3 mL/75 mg) of Diclofenac sodium, Carbopol 940 gel base, will be passively placed in the osseous cavity

All Listed Sponsors
lead

Mariam Hesham Mahmoud Abdelfattah Eissa

OTHER

NCT07101016 - Effect of Local Use of Non-steroidal Anti-inflammatory Agent (Diclofenac Sodium) With and Without Hyaluronidase on Post-surgical Pain and Swelling | Biotech Hunter | Biotech Hunter