Study of Izalontamab Brengitecan (BMS-986507) Versus Platinum-Pemetrexed for EGFR-mutated Non-small Cell Lung Cancer After Failure of EGFR TKI Therapy (IZABRIGHT-Lung01)

PHASE2/PHASE3Not yet recruitingINTERVENTIONAL
Enrollment

596

Participants

Timeline

Start Date

October 15, 2025

Primary Completion Date

September 15, 2028

Study Completion Date

May 15, 2031

Conditions
Non-Small Cell Lung Cancer
Interventions
DRUG

Iza-bren

Specified dose on specified days

DRUG

Carboplatin

Specified dose on specified days

DRUG

Cisplatin

Specified dose on specified days

DRUG

Pemetrexed

Specified dose on specified days

Trial Locations (181)

0

Local Institution - 0006, Santiago

Local Institution - 0245, Jiangmen

Local Institution - 0267, Jingzhou

110

Local Institution - 0047, Taipei

407

Local Institution - 0050, Taichung

704

Local Institution - 0049, Tainan City

1160

Local Institution - 0161, Auderghem

2610

Local Institution - 0280, Wilrijk

3004

Local Institution - 0103, Drammen

5016

Local Institution - 0094, Córdoba

5021

Local Institution - 0106, Bergen

5404

Local Institution - 0188, Baden

5530

Local Institution - 0022, Yvoir

6500

Local Institution - 0189, Bellinzona

9000

Local Institution - 0023, Ghent

9007

Local Institution - 0187, Sankt Gallen

10002

Local Institution - 0048, Taipei

10016

Local Institution - 0090, New York

10043

Local Institution - 0031, Orbassano

10065

Local Institution - 0158, New York

10330

Local Institution - 0264, Bangkok

10408

Local Institution - 0043, Goyang-si

10700

Local Institution - 0265, Bangkok

11217

Local Institution - 0160, Taipei

11501

Local Institution - 0269, Mineola

13125

Local Institution - 0211, Berlin

13620

Local Institution - 0044, Seongnam

13915

Local Institution - 0012, Marseille

14210

Local Institution - 0223, Mexico City

14621

Local Institution - 0186, Rochester

15212

Local Institution - 0088, Pittsburgh

16247

Local Institution - 0046, Suwon

19104

Local Institution - 0205, Philadelphia

20141

Local Institution - 0032, Milan

22307

Local Institution - 0242, Hamburg

22908

Local Institution - 0145, Charlottesville

23298

Local Institution - 0138, Richmond

24105

Local Institution - 0274, Kiel

26121

Local Institution - 0209, Oldenburg

28009

Local Institution - 0175, Madrid

28041

Local Institution - 0206, Madrid

28046

Local Institution - 0176, Madrid

28222

Local Institution - 0181, Majadahonda

28644

Local Institution - 0089, Cheongju-si

29011

Local Institution - 0178, Málaga

30318

Local Institution - 0270, Atlanta

31059

Local Institution - 0017, Toulouse

31203

Local Institution - 0222, Chihuahua City

31904

Local Institution - 0143, Columbus

32610

Local Institution - 0085, Gainesville

33081

Local Institution - 0036, Aviano

34125

Local Institution - 0239, Kassel

37203

Local Institution - 0093, Nashville

38700

Local Institution - 0018, La Tronche

40002

Local Institution - 0272, Mueng

41013

Local Institution - 0182, Seville

43126

Local Institution - 0029, Parma

44106

Local Institution - 0087, Cleveland

44200

Local Institution - 0278, Nantes

44805

Local Institution - 0170, Saint-Herblain

46026

Local Institution - 0180, Valencia

48121

Local Institution - 0028, Ravenna

50009

Local Institution - 0179, Zaragoza

51109

Local Institution - 0213, Cologne

59037

Local Institution - 0010, Lille

60612

Local Institution - 0153, Chicago

63108

Local Institution - 0091, St Louis

67091

Local Institution - 0014, Strasbourg

68020

Local Institution - 0224, Oaxaca City

69126

Local Institution - 0210, Heidelberg

69677

Local Institution - 0162, Bron

70376

Local Institution - 0212, Stuttgart

73730

Local Institution - 0207, Esslingen am Neckar

Local Institution - 0238, Esslingen am Neckar

75248

Local Institution - 0011, Paris

75970

Local Institution - 0015, Paris

77030

Local Institution - 0025, Houston

78229

Local Institution - 0173, San Antonio

80131

Local Institution - 0034, Napoli

81632

Local Institution - 0139, Edwards

82131

Local Institution - 0215, Gauting

82445

Local Institution - 0053, Kaohsiung City

83100

Local Institution - 0137, Avellino

85796

Local Institution - 0219, Bydgoszcz

86609

Local Institution - 0236, Donauwörth

89081

Local Institution - 0241, Ulm

89502

Local Institution - 0276, Reno

90110

Local Institution - 0266, Songkhla

92612

Local Institution - 0279, Irvine

92868

Local Institution - 0154, Orange

94800

Local Institution - 0019, Villejuif

97213

Local Institution - 0038, Portland

97225

Local Institution - 0275, Portland

100142

Local Institution - 0244, Beijing

110001

Local Institution - 0257, Shenyang

110029

Local Institution - 0070, New Delhi

111511

Local Institution - 0228, Bogotá

122001

Local Institution - 0072, Gurugram

130000

Local Institution - 0246, Changchun

169610

Local Institution - 0263, Singapore

200001

Local Institution - 0229, Valledupar

200030

Local Institution - 0250, Shanghai

200032

Local Institution - 0249, Shanghai

200746

Local Institution - 0130, Craiova

221009

Local Institution - 0256, Xuzhou

230002

Local Institution - 0227, Montería

250117

Local Institution - 0248, Jinan

308442

Local Institution - 0262, Singapore

310022

Local Institution - 0252, Hangzhou

317000

Local Institution - 0251, Linhai

330209

Local Institution - 0247, Nanchang

350014

Local Institution - 0253, Fuzhou

380016

Local Institution - 0083, Ahmedabad

380054

Local Institution - 0073, Ahmedabad

400012

Local Institution - 0071, Mumbai

400015

Local Institution - 0133, Cluj-Napoca

400030

Local Institution - 0259, Chongqing

407280

Local Institution - 0132, Florești

410013

Local Institution - 0255, Changsha

430030

Local Institution - 0243, Wuhan

440001

Local Institution - 0097, Nagpur

455000

Local Institution - 0271, Anyang

471003

Local Institution - 0261, Luoyang

530021

Local Institution - 0260, Nanning

560017

Local Institution - 0069, Bengaluru

700106

Local Institution - 0124, Iași

700483

Local Institution - 0119, Iași

711103

Local Institution - 0078, Howrah

760032

Local Institution - 0226, Santiago de Cali

2418515

Local Institution - 0193, Yokohama

7500921

Local Institution - 0005, Santiago

8420383

Local Institution - 0007, Santiago

9810914

Local Institution - 0192, Sendai

02215

Local Institution - 0067, Boston

37404-1130

Local Institution - 0268, Chattanooga

C1426ANZ

Local Institution - 0008, Ciudad Autónoma de Buenos Aires

C1199ABB

Local Institution - 0004, ABB

B-9100

Local Institution - 0024, Sint-Niklaas

T2N 5G2

Local Institution - 0190, Calgary

M5G 2M9

Local Institution - 0183, Toronto

G7H 5H6

Local Institution - 0184, Chicoutimi

H4J 1C5

Local Institution - 0185, Montreal

030000

Local Institution - 0258, Taiyuan

09116

Local Institution - 0208, Chemnitz

115 27

Local Institution - 0054, Athens

124 62

Local Institution - 0060, Chaïdári

540 07

Local Institution - 0056, Thessaloniki

570 10

Local Institution - 0062, Thessaloniki

400 057

Local Institution - 0077, Mumbai

464-8681

Local Institution - 0196, Nagoya

277-8577

Local Institution - 0191, Kashiwa

791-0295

Local Institution - 0203, Tōon

830-0011

Local Institution - 0201, Kurume

003-0804

Local Institution - 0217, Sapporo

663-8501

Local Institution - 0199, Nishinomiya

710-8602

Local Institution - 0200, Kurashiki

573-1191

Local Institution - 0198, Hirakata

589-8511

Local Institution - 0204, Ōsaka-sayama

362-0806

Local Institution - 0194, Ina-machi

431-3192

Local Institution - 0197, Hamamatsu

411-8777

Local Institution - 0195, Nagaizumi-cho,Sunto-gun

135-8550

Local Institution - 0202, Koto-ku

03100

Local Institution - 0225, Mexico City

3844 DG

Local Institution - 0163, Harderwijk

1066 CX

Local Institution - 0216, Amsterdam

1081 HV

Local Institution - 0164, Amsterdam

0450

Local Institution - 0105, Oslo

20-954

Local Institution - 0220, Lublin

81-519

Local Institution - 0231, Gdynia

013812

Local Institution - 0120, Bucharest

022328

Local Institution - 0123, Bucharest

020335

Local Institution - 0115, Bucharest

03080

Local Institution - 0095, Seoul

03722

Local Institution - 0045, Seoul

05505

Local Institution - 0092, Seoul

06351

Local Institution - 0042, Seoul

08035

Local Institution - 0218, Barcelona

08041

Local Institution - 0177, Barcelona

G12 0YN

Local Institution - 0110, Glasgow

SW3 6JJ

Local Institution - 0061, London

E1 1RD

Local Institution - 0140, London

Sponsors
All Listed Sponsors
lead

Bristol-Myers Squibb

INDUSTRY