346
Participants
Start Date
August 31, 2025
Primary Completion Date
December 31, 2028
Study Completion Date
February 28, 2029
Acupuncture
The patient takes a sitting or lateral position. The following acupoints are selected Baihui (GV20), Yintang (EX-HN3), Zhongwan (CV12), Bilateral Neiguan (PC6), Bilateral Zusanli (ST36), Bilateral Sanyinjiao (SP6), Bilateral Gongsun (SP4), Bilateral Pishu (BL20). Electroacupuncture is applied at bilateral Sanyinjiao (SP6) and bilateral Zusanli (ST36) by connecting them to an electroacupuncture device. The needles are retained for 30 minutes.
Sham Acupuncture
sham acupuncture procedure that mirrors the acupuncture treatment in terms of acupoint selection and treatment schedule. However, instead of actual needle insertion, a blunt-tipped sham needle will be used to apply superficial pressure at the designated acupoints. The design of the sham needle includes a base that allows for simulated insertion, providing patients with a mild sensation of pressure and a visual cue as the needle appears to move toward the skin. This innovative approach ensures that while participants experience a similar tactile sensation, there is no penetration of the skin, distinguishing it clearly from the actual acupuncture treatment.
Chemotherapy
Adjuvant chemotherapy with either the XELOX (capecitabine + oxaliplatin) or SOX (S-1 + oxaliplatin) regimen
The first affiliated hospital, Sun Yat-sen University, Guangzhou
Guangdong Provincial Hospital of Chinese Medicine, Guangzhou
Sixth Affiliated Hospital ,Sun Yat-sen University, Guangzhou
Sixth Affiliated Hospital, Sun Yat-sen University
OTHER
First Affiliated Hospital, Sun Yat-Sen University
OTHER
Guangzhou University of Traditional Chinese Medicine
OTHER