NCT07094984 - Comparison of Three Interventions for Antibiotic-Resistant Bacteria (ARB) Decolonization From the Gastrointestinal Tract | Biotech Hunter

Enrollment

360

Participants

Timeline

Start Date

December 31, 2024

Primary Completion Date

February 1, 2027

Study Completion Date

April 30, 2027

Conditions

Drug Resistance, BacterialAntimicrobial Drug Resistance

Interventions

OTHER

Fecal microbiota transplantation (FMT)

FMT administered after antibiotic pre-treatment and bowel cleansing. Delivered either in capsule form or via colonoscopy to restore healthy gut microbiota and support decolonization of ARB.

DIETARY_SUPPLEMENT

Probiotic Therapy

Oral administration of a high-dose multistrain probiotic containing Lactobacillus, Bifidobacterium, and Streptococcus strains for 20 days following bowel cleansing.

OTHER

Gut Microbiota Boosting Diet

A structured 38-day diet designed to promote eubiosis and support spontaneous ARB decolonization. Meals are tailored and delivered to patients based on clinical nutrition protocols.

Trial Locations (1)

Unknown

RECRUITING

Uniwersyteckie Centrum Kliniczne Warszawskiego Uniwersytetu Medycznego, Klinika Hematologii, Transplantologii i Chorób Wewnętrznych, Warsaw