50
Participants
Start Date
November 30, 2025
Primary Completion Date
December 31, 2027
Study Completion Date
December 31, 2027
Isometric handgrip exercise training
Maximum voluntary contraction (MVC) will be assessed first in both hands using a hand dynamometer with a digital display (Handexer HFEH20); the participant squeezes the hand dynamometer as hard as they can for 3 to 5 attempts to obtain the MVC. The intervention is an 8- week training protocol that consists of handgrip exercises performed by the participant at home. Each cycle of sustained handgrip exercise consists of sustained squeezing of the hand dynamometer at 30% of MVC for 2 minutes (i.e. isometric) followed by 1 minute of rest.
Sham Training
Each cycle of sustained handgrip exercise consists of sustained squeezing of the hand dynamometer at 3 - 5% of MVC rather than 30%.
RECRUITING
Emory University, Atlanta
American Heart Association
OTHER
Emory University
OTHER