70
Participants
Start Date
July 20, 2025
Primary Completion Date
October 20, 2025
Study Completion Date
October 20, 2025
Lung protective ventilation
The patient in this group will receive tidal volume at 6-8 ml/kg of ideal body weight with PEEP of 5 cm of H2O and plateau pressure will be kept less than 30cm of H2O.
Driving pressure guided ventilation
They will receive tidal volume of 6-8 ml/kg of ideal body weight and initial PEEP of 5 cm of water. Principal investigator will then incrementally increase PEEP by 2 cm of water till a value 15 cm of water PEEP is reached or Plateau pressure becomes equal to 30 cm of water or driving pressure starts to increase or there is change in any hemodynamics. Each incremental PEEP will last for 3 respiratory cycles before moving on to next value. PEEP value with lowest driving pressure will then be selected for the duration of surgical procedure
RECRUITING
Benazir Bhutto Hospital, Rawalpindi
Rawalpindi Medical College
OTHER