NCT07092215 - Mechanisms of Pain Hypersensitivity in a Human Skin Inflammation Model | Biotech Hunter

Enrollment

Participants

Timeline

Start Date

June 17, 2025

Primary Completion Date

July 11, 2025

Study Completion Date

July 11, 2025

Conditions

Pain

Interventions

DRUG

Synthetic interstitial fluid (SIF) / SIF neutral pH

Intradermal injection of SIF at time point -4.5h, followed by laser speckle imaging, mechanical stimulation and intradermal injection of SIF with neutral pH (pH 7.4)

DRUG

Synthetic interstitial fluid (SIF) / SIF acidic pH

Intradermal injection of SIF at time point -4.5h, followed by laser speckle imaging, mechanical stimulation and intradermal injection of SIF with acidic pH (pH 7.4 to pH 5.7)

DRUG

Synthetic interstitial fluid (SIF) / SIF acidic pH + BCTC 1 µM

Intradermal injection of SIF at time point -4.5h, followed by laser speckle imaging, mechanical stimulation and intradermal injection of SIF with acidic pH (pH 7.4 to pH 5.7), containing BCTC 1 µM

DRUG

LPS 5 ng / SIF neutral pH

Intradermal injection of LPS 5 ng at time point -4.5h, followed by laser speckle imaging, mechanical stimulation and intradermal injection of SIF with neutral pH (pH 7.4)

DRUG

LPS 5 ng / SIF acidic pH

Intradermal injection of LPS 5 ng at time point -4.5h, followed by laser speckle imaging, mechanical stimulation and intradermal injection of SIF with acidic pH (pH 7.4 to pH 5.7)

DRUG

LPS 5 ng / SIF acidic pH + BCTC 1 µM

Intradermal injection of LPS 5 ng at time point -4.5h, followed by laser speckle imaging, mechanical stimulation and intradermal injection of SIF with acidic pH (pH 7.4 to pH 5.7), containing BCTC 1 µM

DRUG

LPS 5 ng + Azeliragon 100 µM / SIF neutral pH

Intradermal injection of LPS 5 ng + Azeliragon 100 µM at time point -4.5h, followed by laser speckle imaging, mechanical stimulation and intradermal injection of SIF with neutral pH (pH 7.4)

DRUG

LPS 5 ng + Azeliragon 100 µM / SIF acidic pH

Intradermal injection of LPS 5 ng + Azeliragon 100 µM at time point -4.5h, followed by laser speckle imaging, mechanical stimulation and intradermal injection of SIF with acidic pH (pH 7.4 to 5.7)

DRUG

LPS 5 ng + Resatorvid 10 µM / SIF neutral pH

Intradermal injection of LPS 5 ng + Resatorvid 10 µM at time point -4.5h, followed by laser speckle imaging, mechanical stimulation and intradermal injection of SIF with neutral pH (pH 7.4)

DRUG

LPS 5 ng + Resatorvid 10 µM / SIF acidic pH

Intradermal injection of LPS 5 ng + Resatorvid 10 µM at time point -4.5h, followed by laser speckle imaging, mechanical stimulation and intradermal injection of SIF with neutral pH (pH 7.4 to pH 5.7)

Trial Locations (1)

1090

Medical University of Vienna, Vienna

All Listed Sponsors

lead

Stefan Heber

OTHER