NCT07087379View on ClinicalTrials.gov

Perioperative Intensive Statin Therapy for Neuroprotection in TAVR（PISTNT）

PHASE4Not yet recruitingINTERVENTIONAL
Enrollment

500

Participants

Timeline

Start Date

October 1, 2025

Primary Completion Date

October 1, 2027

Study Completion Date

January 1, 2028

Conditions
Aortic StenosisCerebral Ischaemic Injury
Interventions
DRUG

Intensive statin treatment

"Intensive statin group:~Atorvastatin 80mg, orally administered 12 hours before surgery Atorvastatin 80mg, orally administered 2 hours before surgery"

DRUG

Placebo Control

Placebo, tablets, oral administration 12 hours before surgery Placebo, tablet, oral administration 2 hours before surgery

All Listed Sponsors
lead

Pan Xiangbin

OTHER