Vadadustat for the Treatment of Nonintubated Acute Respiratory Distress Syndrome Due to Pathogen-Associated Lung Injury

PHASE2/PHASE3Not yet recruitingINTERVENTIONAL
Enrollment

1,100

Participants

Timeline

Start Date

August 1, 2025

Primary Completion Date

July 1, 2026

Study Completion Date

July 1, 2026

Conditions
Nonintubated Acute Respiratory Distress Syndrome (ARDS)Pathogen-associated Lung Injury
Interventions
DRUG

Vadadustat 900mg

Participants will receive 900mg vadadustat (as oral tablets) for 14 days or until the date of discharge, whichever comes first, at approximately the same time each day without regard for timing of meals.

DRUG

Vadadustat 1200mg

Participants will receive 1200mg vadadustat (as oral tablets) for 14 days or until the date of discharge, whichever comes first, at approximately the same time each day without regard for timing of meals.

DRUG

Placebo

Participants will matching placebo (as oral tablets) for 14 days or until the date of discharge, whichever comes first, at approximately the same time each day without regard for timing of meals.

Trial Locations (1)

77030

The University of Texas Health Science Center at Houston, Houston

Sponsors

Collaborators (1)

All Listed Sponsors
collaborator

Akebia Therapeutics Inc.

UNKNOWN

lead

Bentley J. Bobrow

OTHER