Small Molecules
Total Trials
39
As Lead Sponsor
34
As Collaborator
5
Total Enrollment
14,418
NCT04707573
Study to Assess the Safety and Pharmacokinetics of AKB-6548 in Participants With Chronic Kidney Disease (CKD), Stages 3 and 4
Phase: Phase 2
Role: Lead Sponsor
Start: Jul 8, 2010
Completion: Sep 24, 2010
NCT01235936
Safety and Efficacy Study for AKB-6548 in Participants With Chronic Kidney Disease and Anemia
Start: Oct 21, 2010
Completion: May 31, 2011
NCT01381094
42-Day Repeat Oral Dose Study of AKB-6548 in Participants With Chronic Kidney Disease and Anemia
Start: Jun 15, 2011
Completion: Feb 16, 2012
NCT01906489
20-Week Repeat Oral Dose Study of AKB-6548 in Participants With Chronic Kidney Disease and Anemia
Start: Jul 23, 2013
Completion: Sep 3, 2014
NCT02062203
Effect of AKB-6548 on Cardiac Repolarization Intervals in Healthy Volunteers
Phase: Phase 1
Start: Jan 31, 2014
Completion: Apr 30, 2014
NCT02260193
16-Week Repeat Oral Dose Study of AKB-6548 for Anemia in Participants With End Stage Renal Disease (ESRD) Requiring Chronic Hemodialysis
Start: Sep 10, 2014
Completion: Jul 22, 2015
NCT02327546
Effects of Ferrous Sulfate on the Pharmacokinetics of AKB-6548
Start: Dec 31, 2014
Completion: Feb 28, 2015
NCT02412449
Relative Bioavailability of Two Formulations of AKB-6548 and the Food Effect of a New Tablet in Healthy Adult Subjects
Start: Apr 30, 2015
Completion: Apr 30, 2015
NCT02502500
Effect of AKB-6548 on the Pharmacokinetics of Celecoxib
Start: Jul 31, 2015
Completion: Sep 30, 2015
NCT02648347
Study to Evaluate Vadadustat for the Correction of Anemia in Participants With Non-dialysis-dependent Chronic Kidney Disease
Phase: Phase 3
Start: Dec 31, 2015
Completion: Jul 31, 2020
NCT02680574
Efficacy and Safety Study to Evaluate Vadadustat for the Maintenance Treatment of Anemia in Participants With Non-dialysis-dependent Chronic Kidney Disease (NDD-CKD)
Start: Feb 29, 2016
NCT02865850
Efficacy and Safety Study to Evaluate Vadadustat for the Correction or Maintenance Treatment of Anemia in Participants With Incident Dialysis-dependent Chronic Kidney Disease (DD-CKD)
Start: Jul 31, 2016
Completion: Mar 30, 2020
NCT02892149
Efficacy and Safety Study to Evaluate Vadadustat for the Maintenance Treatment of Anemia in Participants With Dialysis-dependent Chronic Kidney Disease (DD-CKD)
Start: Aug 31, 2016
NCT03054337
Dose-Finding Study of Vadadustat in Japanese Subjects With Anemia Secondary to Non-Dialysis Dependent Chronic Kidney Disease (NDD-CKD)
Start: Oct 31, 2016
Completion: Aug 28, 2017
NCT03054350
Dose-Finding Study of Vadadustat in Japanese Subjects With Anemia Secondary to Dialysis-Dependent Chronic Kidney Disease (DD-CKD)
Start: Dec 31, 2016
Completion: Jan 24, 2018
NCT03140722
Study to Evaluate Vadadustat for Anemia in Subjects With Dialysis-Dependent Chronic Kidney Disease (DD-CKD) Who Are Hyporesponsive to Erythropoiesis Stimulating Agents
Start: May 2, 2017
Completion: Mar 21, 2018
NCT03217591
A Study to Evaluate the Soluble Guanylate Cyclase (sGC) Stimulator IW-1973 in Diabetic Nephropathy / Diabetic Kidney Disease as Measured by Albuminuria
Start: Aug 1, 2017
Completion: Aug 20, 2019
NCT03242967
Study to Evaluate Three Times Per Week (TIW) Oral Dosing of Vadadustat for Anemia in Subjects With Dialysis-Dependent Chronic Kidney Disease (DD-CKD)
Start: Aug 31, 2017
Completion: Feb 12, 2018
NCT03254485
A Study of the Effect of IW-1973 on the Exercise Capacity of Patients With Heart Failure With Preserved Ejection Fraction (HFpEF)
Start: Nov 7, 2017
Completion: Aug 19, 2019
NCT03639155
A Study in Evaluating Bioequivalence Between Test and Reference Formulations of Vadadustat Tablets in Healthy Adults
Start: Apr 12, 2018
Completion: May 23, 2018
NCT03799848
A Single Dose Study of Oral Vadadustat in Subjects With Normal and Impaired Hepatic Function
Start: Jun 12, 2018
Completion: Oct 18, 2018
NCT03801733
Drug-Drug Interaction Study of Vadadustat With Rosuvastatin, Sulfasalazine, Pravastatin, Atorvastatin and Simvastatin
Start: Jun 17, 2018
Completion: Nov 24, 2018
NCT03801746
Drug-Drug Interaction Study of Vadadustat With Cyclosporine, Probenecid and Rifampin
Start: Jul 20, 2018
Completion: Aug 15, 2018
NCT03801759
Drug-Drug Interaction Study of Vadadustat With Digoxin, Adefovir and Furosemide
Completion: Sep 30, 2018
NCT03657290
A Study in Evaluating Bioequivalence of Test and Reference Vadadustat 450 MG and 150 MG Tablets and to Determine Food Effect on the 450 MG Tablet
Start: Aug 3, 2018
Completion: Oct 16, 2018
NCT03789032
Study to Evaluate the Effect of Rabeprazole on the Pharmacokinetics of Vadadustat
Start: Oct 3, 2018
Completion: Nov 19, 2018
NCT03799627
Study of Vadadustat in Hemodialysis Participants With Anemia Switching From Epoetin Alfa
Start: Jan 31, 2019
Completion: Jul 15, 2020
NCT03992066
Study to Evaluate the Pharmacokinetics, Pharmacodynamics, and Safety of Vadadustat in Hemodialysis Subjects With Anemia Associated With Chronic Kidney Disease
Start: May 28, 2019
NCT04313153
Trial Evaluating the Efficacy and Safety of Oral Vadadustat Once Daily (QD) and Three Times Weekly (TIW) for the Maintenance Treatment of Anemia in Hemodialysis Subjects Converting From Erythropoiesis-Stimulating Agents (ESAs)
Start: May 27, 2020
Completion: Jun 22, 2022
NCT04299633
Study in Healthy Adult Subjects to Assess the Effect of Phosphate Binders on the Pharmacokinetics of a Single Dose of Vadadustat
Start: Jun 15, 2020
Completion: Sep 28, 2020
NCT04478071
Vadadustat for the Prevention and Treatment of Acute Respiratory Distress Syndrome (ARDS) in Hospitalized Patients With Coronavirus Disease 2019 (COVID-19)
Role: Collaborator
Start: Aug 22, 2020
Completion: Mar 25, 2022
NCT04707768
Study Evaluating the Efficacy and Safety of Dose Conversion From a Long-acting Erythropoiesis-stimulating Agent (Mircera®) to Three Times Weekly Oral Vadadustat for the Maintenance Treatment of Anemia in Hemodialysis Subjects
Start: Jun 18, 2021
Completion: Jan 30, 2023
NCT04922645
Auryxia (Ferric Citrate) Therapy for In-Center and Home Dialysis Participants
Phase: Phase 4
Start: Jun 29, 2021
Completion: Sep 15, 2022
NCT05085275
Ferric Citrate for the Prevention of Renal Failure in Adults With Advanced Chronic Kidney Disease
Start: Mar 30, 2022
Completion: Jan 24, 2024
NCT06520826
Vafseo Outcomes In-Center Experience
Start: Nov 20, 2024
Completion: Jun 30, 2026
NCT05082571
Study to Evaluate the Safety and Efficacy of Oral Vadadustat in Pediatric Participants With Anemia of Chronic Kidney Disease
Start: Jan 31, 2025
Completion: Oct 31, 2026
NCT05082584
Study to Evaluate the Safety and Efficacy of Oral Vadadustat in Pediatric Participants With Anemia of Chronic Kidney Disease Naive to Erythropoiesis-Stimulating Agents
NCT06901505
To Evaluate the Efficacy of Three Times Weekly (TIW) Vadadustat Compared to Standard of Care ESA in Patients With Anemia of CKD Receiving In-Center Hemodialysis
Start: Jul 24, 2025
NCT07086755
Vadadustat for the Treatment of Nonintubated Acute Respiratory Distress Syndrome Due to Pathogen-Associated Lung Injury
Phase: Phase 2/3
Start: Aug 1, 2025
Completion: Jul 1, 2026
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