The Effect of Sitagliptin, Pioglitazone and Dapagliflozine on Myocardial Infarction in Diabetic Rats

PHASE4CompletedINTERVENTIONAL
Enrollment

50

Participants

Timeline

Start Date

October 30, 2024

Primary Completion Date

October 30, 2024

Study Completion Date

November 30, 2024

Conditions
DiabeticMyocardial Infarction
Interventions
DIETARY_SUPPLEMENT

standard normal diet

Group I: formed of normal animals. They were allowed standard normal diet and water. They received no drugs

DRUG

low dose Streptozotocin

Non-treated diabetic rats; diabetes was induced by administration of 20% fructose solution in drinking water for 2 weeks, then intra peritoneal injection of a low dose STZ (40 mg/kg b.w.), was done

DRUG

Sitagliptin (Novartis, USA)

Sitagliptin treated diabetic group sitagliptin was administered by gastric gavage in a dose 10mg/ kg /day for 4 weeks

DRUG

Pioglitazone hydrochloride (Unipharma., Egypt)

Pioglitazone treated diabetic group (G4); Pioglitazone was administered by gastric gavage in a dose 10 mg/ kg /day for 4 weeks

DRUG

Dapagliflozine hemihydrate (Janssen, USA)

Dapagliflozine treated diabetic group (G5); Dapagliflozine was administered by gastric gavage in a dose 1mg/ kg /day for 4 weeks

Trial Locations (1)

Unknown

Alazher University.assuit Branch, Asyut

All Listed Sponsors
lead

Al-Azhar University

OTHER

NCT07083232 - The Effect of Sitagliptin, Pioglitazone and Dapagliflozine on Myocardial Infarction in Diabetic Rats | Biotech Hunter | Biotech Hunter