NCT07076342View on ClinicalTrials.gov

The Role of mGluR5 in CBT-I

PHASE4RecruitingINTERVENTIONAL
Enrollment

42

Participants

Timeline

Start Date

August 1, 2025

Primary Completion Date

June 30, 2030

Study Completion Date

June 30, 2030

Conditions
Major Depressive Disorder (MDD)
Interventions
BEHAVIORAL

Cognitive Behavioral Therapy for Insomnia

Cognitive Behavioral Therapy for Insomnia (CBT-I) will be delivered through an online program, Sleep Healthy Using The Internet Sleep Healthy Using The Internet (SHUTi)

DRUG

PET Scan with [11C]ABP688

Prior to and after completing the CBT-I protocol, participants will undergo a PET scan using tracer \[11C\]ABP688) to quantify hippocampal mGluR5 density.

Trial Locations (1)

11794

RECRUITING

Stony Brook University: Dept of Psychiatry, Stony Brook

All Listed Sponsors
collaborator

National Institutes of Health (NIH)

NIH

collaborator

National Institute of Mental Health (NIMH)

NIH

lead

Stony Brook University

OTHER