A Study of Novel Agents or Combinations as Perioperative Treatment in Participants With Locally Advanced Resectable Gastroesophageal Adenocarcinoma

PHASE2RecruitingINTERVENTIONAL
Enrollment

100

Participants

Timeline

Start Date

July 17, 2025

Primary Completion Date

December 9, 2026

Study Completion Date

September 6, 2028

Conditions
Gastroesophageal Adenocarcinoma
Interventions
DRUG

AZD0901

AZD0901 will be administered as an IV infusion.

DRUG

Rilvegostomig

Rilvegostomig will be administered as an IV infusion.

DRUG

Trastuzumab Deruxtecan (T-DXd)

T-DXd will be administered as an IV infusion.

DRUG

Capecitabine

Capecitabine (Fluoropyrimidine) will be administered orally as chemotherapy standard of care.

DRUG

5-Fluorouracil (5-FU)

5-FU (Fluoropyrimidine) will be administered as an IV infusion as chemotherapy standard of care.

DRUG

FLOT Chemotherapy

FLOT (5-FU, leucovorin, oxaliplatin, and docetaxel) Chemotherapy will be administered as an IV infusion.

Trial Locations (64)

704

NOT_YET_RECRUITING

Research Site, Tainan City

10032

NOT_YET_RECRUITING

Research Site, New York

10065

NOT_YET_RECRUITING

Research Site, New York

11217

NOT_YET_RECRUITING

Research Site, Taipei

15232

NOT_YET_RECRUITING

Research Site, Pittsburgh

19713

NOT_YET_RECRUITING

Research Site, Newark

20007

NOT_YET_RECRUITING

Research Site, Washington D.C.

20089

NOT_YET_RECRUITING

Research Site, Rozzano

20133

NOT_YET_RECRUITING

Research Site, Milan

20141

NOT_YET_RECRUITING

Research Site, Milan

20162

NOT_YET_RECRUITING

Research Site, Milan

25240

NOT_YET_RECRUITING

Research Site, Erzurum

28007

NOT_YET_RECRUITING

Research Site, Madrid

29010

NOT_YET_RECRUITING

Research Site, Málaga

32005

NOT_YET_RECRUITING

Research Site, Ourense

33011

NOT_YET_RECRUITING

Research Site, Oviedo

33100

NOT_YET_RECRUITING

Research Site, Udine

33305

NOT_YET_RECRUITING

Research Site, Taoyuan District

34098

NOT_YET_RECRUITING

Research Site, Fatih-Istanbul

34722

NOT_YET_RECRUITING

Research Site, Istanbul

36100

NOT_YET_RECRUITING

Research Site, Vicenza

39008

NOT_YET_RECRUITING

Research Site, Santander

41124

NOT_YET_RECRUITING

Research Site, Modena

46010

NOT_YET_RECRUITING

Research Site, Valencia

49444

RECRUITING

Research Site, North Shores

50134

NOT_YET_RECRUITING

Research Site, Florence

54100

NOT_YET_RECRUITING

Research Site, Adapazarı

56100

NOT_YET_RECRUITING

Research Site, Pisa

66205

NOT_YET_RECRUITING

Research Site, Fairway

80756

NOT_YET_RECRUITING

Research Site, Kaohsiung City

100142

RECRUITING

Research Site, Beijing

130021

NOT_YET_RECRUITING

Research Site, Changchun

200025

NOT_YET_RECRUITING

Research Site, Shanghai

266003

NOT_YET_RECRUITING

Research Site, Qingdao

310003

NOT_YET_RECRUITING

Research Site, Hangzhou

350014

NOT_YET_RECRUITING

Research Site, Fuzhou

610041

NOT_YET_RECRUITING

Research Site, Chengdu

650118

NOT_YET_RECRUITING

Research Site, Kunming

M5G 2M9

NOT_YET_RECRUITING

Research Site, Toronto

H2X 3E4

NOT_YET_RECRUITING

Research Site, Montreal

H4A 3J1

NOT_YET_RECRUITING

Research Site, Montreal

0112

NOT_YET_RECRUITING

Research Site, Tbilisi

0114

NOT_YET_RECRUITING

Research Site, Tbilisi

0144

NOT_YET_RECRUITING

Research Site, Tbilisi

0177

NOT_YET_RECRUITING

Research Site, Tbilisi

104-0045

RECRUITING

Research Site, Chūōku

812-8582

NOT_YET_RECRUITING

Research Site, Fukuoka

350-1298

NOT_YET_RECRUITING

Research Site, Hidaka-shi

277-8577

NOT_YET_RECRUITING

Research Site, Kashiwa

362-0806

NOT_YET_RECRUITING

Research Site, Kitaadachi-gun

135-8550

NOT_YET_RECRUITING

Research Site, Kōtoku

464-8681

NOT_YET_RECRUITING

Research Site, Nagoya

541-8567

NOT_YET_RECRUITING

Research Site, Osaka

558-8558

NOT_YET_RECRUITING

Research Site, Osaka

565-0871

NOT_YET_RECRUITING

Research Site, Suita-shi

15-027

WITHDRAWN

Research Site, Bialystok

02-034

WITHDRAWN

Research Site, Warsaw

08035

NOT_YET_RECRUITING

Research Site, Barcelona

08036

NOT_YET_RECRUITING

Research Site, Barcelona

03203

NOT_YET_RECRUITING

Research Site, Elche

BS2 8ED

NOT_YET_RECRUITING

Research Site, Bristol

DD1 9SY

NOT_YET_RECRUITING

Research Site, Dundee

OX3 7LJ

NOT_YET_RECRUITING

Research Site, Headington

NR4 7UY

NOT_YET_RECRUITING

Research Site, Norwich

Sponsors

Lead Sponsor

Collaborators (1)

All Listed Sponsors
collaborator

Parexel

INDUSTRY

lead

AstraZeneca

INDUSTRY