Hydroxyapatite Toothpastes and Enamel Remineralization:

NARecruitingINTERVENTIONAL
Enrollment

40

Participants

Timeline

Start Date

July 25, 2025

Primary Completion Date

January 30, 2026

Study Completion Date

February 15, 2026

Conditions
Enamel HypomineralizationTooth Erosion
Interventions
DRUG

Biorepair® Total Protection Plus Toothpaste

Participants will use Biorepair® Total Protection Plus toothpaste twice daily for 6 months. The toothpaste contains biomimetic microRepair® particles based on zinc-substituted hydroxyapatite, intended to promote enamel remineralization, reduce sensitivity, and protect against erosion and plaque accumulation. Professional dental cleanings will also be performed every 3 months.

DRUG

Bioniq® Toothpaste

Participants will use Bioniq® Repair toothpaste twice daily for 6 months. The toothpaste contains 20% conventional hydroxyapatite and is designed to restore enamel, reduce dentin hypersensitivity, and protect against erosion. Professional dental cleanings will also be performed every 3 months.

Trial Locations (1)

27100

RECRUITING

Unit of Orthodontics and Pediatric Dentistry - Section of Dentistry - Department of Clinical, Surgical, Diagnostic and Pediatrics - University of Pavia, Pavia

All Listed Sponsors
lead

University of Pavia

OTHER

NCT07069218 - Hydroxyapatite Toothpastes and Enamel Remineralization: | Biotech Hunter | Biotech Hunter