Para-Probiotic Oral Care in Periodontal Patients With Type 2 Diabetes

NARecruitingINTERVENTIONAL
Enrollment

40

Participants

Timeline

Start Date

July 30, 2025

Primary Completion Date

January 30, 2026

Study Completion Date

February 15, 2026

Conditions
PeriodontitisType 2 Diabetes Mellitus (T2DM)
Interventions
DRUG

Para-probiotic oral care

This intervention includes the home use of a para-probiotic-based toothpaste (Biorepair Plus Parodontogel) and mouthwash (Biorepair Plus with para-probiotics), applied twice daily for 15 days after each recall visit, over a 6-month period. The products contain microRepair® (zinc hydroxyapatite), lactoferrin, zinc PCA, and para-probiotic extracts aimed at modulating the oral microbiota and improving periodontal health.

DRUG

Chlorhexidine oral care

This intervention includes the home use of toothpaste and mouthwash containing 0.20% chlorhexidine digluconate, applied twice daily for 15 days after each recall visit, over a 6-month period. Chlorhexidine is used for its antimicrobial properties to control dental plaque and gingival inflammation.

Trial Locations (1)

27100

RECRUITING

Unit of Orthodontics and Pediatric Dentistry - Section of Dentistry - Department of Clinical, Surgical, Diagnostic and Pediatrics - University of Pavia, Pavia

All Listed Sponsors
lead

University of Pavia

OTHER