Study on the Intervention Effect of Denosumab on High-Risk Patients With Osteoporotic Fractures in Type 2 Diabetes

NANot yet recruitingINTERVENTIONAL
Enrollment

310

Participants

Timeline

Start Date

August 1, 2025

Primary Completion Date

July 31, 2026

Study Completion Date

July 31, 2026

Conditions
Type 2 DiabetesOsteoporosisFractures
Interventions
DRUG

Denosumab treatment in type 2 diabetes mellitus (T2DM) with osteoporosis patients

"1. Antihyperglycemic drug therapy: Follow the Chinese Diabetes Treatment Guidelines and clinical practice standards. Adjust the antihyperglycemic regimen based on blood glucose levels, with a target HbA1c of below 7.5%.~2. Denosumab treatment: Administer 60 mg of denosumab via subcutaneous injection every six months for a total treatment period of one year."

DRUG

Eldecalcitol treatment in type 2 diabetes mellitus (T2DM) with osteoporosis patients

"1. Antihyperglycemic drug therapy: Follow the Chinese Diabetes Treatment Guidelines and clinical practice standards. Adjust the antihyperglycemic regimen based on blood glucose levels, with a target HbA1c of below 7.5%.~2. Eldecalcitol treatment: Eldecalcitol, 0.75 µg per capsule, taken orally once daily for a total treatment period of one year."

Trial Locations (4)

100730

Peking Union Medical College Hospital, Beijing

Unknown

Huai'an First People's Hospital, Huai'an

Jiangxi Provincial People's Hospital, Jiangxi

Kunshan Hospital of Traditional Chinese Medicine, Kunshan

All Listed Sponsors
lead

Peking Union Medical College Hospital

OTHER