A Study to Compare the Combination of BMS-986504 With Pembrolizumab and Chemotherapy Versus Placebo Plus Pembrolizumab and Chemotherapy in First-line Metastatic Non-small Cell Lung Cancer Participants With Homozygous MTAP Deletion

PHASE2/PHASE3RecruitingINTERVENTIONAL
Enrollment

590

Participants

Timeline

Start Date

October 6, 2025

Primary Completion Date

August 12, 2031

Study Completion Date

August 12, 2031

Conditions
Metastatic Non-small Cell Lung Cancer With MTAP Deletion
Interventions
DRUG

BMS-986504

Specified dose on specified days

DRUG

Pembrolizumab

Specified dose on specified days

OTHER

Placebo

Specified dose on specified days

DRUG

Cisplatin

Specified dose on specified days

DRUG

Carboplatin

Specified dose on specified days

DRUG

Pemetrexed

Specified dose on specified days

DRUG

Paclitaxel

Specified dose on specified days

DRUG

Nab-paclitaxel

Specified dose on specified days

Trial Locations (241)

0

NOT_YET_RECRUITING

Local Institution - 0099, Guangzhou

NOT_YET_RECRUITING

Local Institution - 0285, Hksar

NOT_YET_RECRUITING

Local Institution - 0323, Shatin

110

RECRUITING

Taipei Medical University Hospital, Taipei

333

NOT_YET_RECRUITING

Local Institution - 0112, Taoyuan District

704

NOT_YET_RECRUITING

Local Institution - 0111, Tainan City

1083

NOT_YET_RECRUITING

Local Institution - 0288, Budapest

1090

NOT_YET_RECRUITING

Local Institution - 0342, Brussels

1210

NOT_YET_RECRUITING

Local Institution - 0207, Vienna

1426

NOT_YET_RECRUITING

Local Institution - 0447, Buenos Aires

2100

NOT_YET_RECRUITING

Local Institution - 0356, Copenhagen

2170

NOT_YET_RECRUITING

Local Institution - 0432, Liverpool

2650

NOT_YET_RECRUITING

Local Institution - 0227, Edegem

3004

NOT_YET_RECRUITING

Local Institution - 0096, Drammen

3200

NOT_YET_RECRUITING

Local Institution - 0291, Gyöngyös

3350

NOT_YET_RECRUITING

Local Institution - 0367, Ballarat Central

3500

NOT_YET_RECRUITING

Local Institution - 0226, Hasselt

4000

NOT_YET_RECRUITING

Local Institution - 0340, Liège

4500

NOT_YET_RECRUITING

Local Institution - 0315, Panagyurishte

4575

NOT_YET_RECRUITING

Local Institution - 0382, Birtinya

5112

NOT_YET_RECRUITING

Local Institution - 0381, Elizabeth Vale

5530

NOT_YET_RECRUITING

Local Institution - 0225, Yvoir

5700

NOT_YET_RECRUITING

Local Institution - 0290, Gyula

6000

NOT_YET_RECRUITING

Local Institution - 0307, Stara Zagora

6300

NOT_YET_RECRUITING

Local Institution - 0309, Haskovo

7000

NOT_YET_RECRUITING

Local Institution - 0431, Hobart

7002

NOT_YET_RECRUITING

Local Institution - 0308, Rousse

8582

NOT_YET_RECRUITING

Local Institution - 0287, Farkasgyepű

8800

NOT_YET_RECRUITING

Local Institution - 0277, Roeselare

10002

NOT_YET_RECRUITING

Local Institution - 0113, Taipei

10043

NOT_YET_RECRUITING

Local Institution - 0037, Orbassano

10330

NOT_YET_RECRUITING

Local Institution - 0411, Bangkok

10408

NOT_YET_RECRUITING

Local Institution - 0271, Goyang-si

10532

NOT_YET_RECRUITING

Local Institution - 0179, Hawthorne

10700

NOT_YET_RECRUITING

Local Institution - 0412, Bangkok

13273

NOT_YET_RECRUITING

Local Institution - 0224, Marseille

13620

NOT_YET_RECRUITING

Local Institution - 0273, Seongnam

14076

NOT_YET_RECRUITING

Local Institution - 0217, Caen

14642

NOT_YET_RECRUITING

Local Institution - 0128, Rochester

16059

NOT_YET_RECRUITING

Local Institution - 0320, Bursa

20132

NOT_YET_RECRUITING

Local Institution - 0045, Milan

20133

NOT_YET_RECRUITING

Local Institution - 0039, Milan

21079

NOT_YET_RECRUITING

Local Institution - 0212, Dijon

22030

NOT_YET_RECRUITING

Local Institution - 0319, Edirne

22031

WITHDRAWN

Local Institution - 0131, Fairfax

23298

NOT_YET_RECRUITING

Local Institution - 0186, Richmond

25000

NOT_YET_RECRUITING

Local Institution - 0341, Besançon

26504

NOT_YET_RECRUITING

Local Institution - 0008, Pátrai

28009

NOT_YET_RECRUITING

Local Institution - 0118, Madrid

28041

NOT_YET_RECRUITING

Local Institution - 0254, Madrid

28222

NOT_YET_RECRUITING

Local Institution - 0252, Majadahonda

28644

NOT_YET_RECRUITING

Local Institution - 0272, Cheongju-si

29011

NOT_YET_RECRUITING

Local Institution - 0117, Málaga

29200

NOT_YET_RECRUITING

Local Institution - 0221, Brest

31059

NOT_YET_RECRUITING

Local Institution - 0216, Toulouse

31203

NOT_YET_RECRUITING

Local Institution - 0327, Chihuahua City

32224

NOT_YET_RECRUITING

Local Institution - 0389, Jacksonville

33081

NOT_YET_RECRUITING

Local Institution - 0042, Aviano

33316

NOT_YET_RECRUITING

Local Institution - 0152, Fort Lauderdale

33600

NOT_YET_RECRUITING

Local Institution - 0219, Pessac

33709

WITHDRAWN

Local Institution - 0430, St. Petersburg

34298

NOT_YET_RECRUITING

Local Institution - 0220, Montpellier

35033

NOT_YET_RECRUITING

Local Institution - 0222, Rennes

37032

NOT_YET_RECRUITING

Local Institution - 0338, Tours

40138

NOT_YET_RECRUITING

Local Institution - 0098, Bologna

40503

NOT_YET_RECRUITING

Local Institution - 0333, Lexington

40536

NOT_YET_RECRUITING

Local Institution - 0125, Lexington

41013

NOT_YET_RECRUITING

Local Institution - 0256, Seville

41110

NOT_YET_RECRUITING

Local Institution - 0003, Larissa

43210

NOT_YET_RECRUITING

Local Institution - 0129, Columbus

44195

NOT_YET_RECRUITING

Local Institution - 0163, Cleveland

44260

NOT_YET_RECRUITING

Local Institution - 0296, Guadalajara

44680

NOT_YET_RECRUITING

Local Institution - 0326, Guadalajara

44800

NOT_YET_RECRUITING

Local Institution - 0215, Saint-Herblain

46026

NOT_YET_RECRUITING

Local Institution - 0255, Valencia

48121

NOT_YET_RECRUITING

Local Institution - 0035, Ravenna

48201

NOT_YET_RECRUITING

Local Institution - 0405, Detroit

49684

NOT_YET_RECRUITING

Local Institution - 0420, Traverse City

54511

NOT_YET_RECRUITING

Local Institution - 0211, Vandœuvre-lès-Nancy

55905

NOT_YET_RECRUITING

Local Institution - 0182, Rochester

59100

NOT_YET_RECRUITING

Local Institution - 0413, Kuala Lumpur

63000

NOT_YET_RECRUITING

Local Institution - 0223, Clermont-Ferrand

66460

NOT_YET_RECRUITING

Local Institution - 0298, Monterrey

68020

NOT_YET_RECRUITING

Local Institution - 0297, Oaxaca City

68130

RECRUITING

Oncology Hematology West P.C. dba Nebraska Cancer Specialists, Omaha

69310

NOT_YET_RECRUITING

Local Institution - 0214, Pierre-Bénite

72530

NOT_YET_RECRUITING

Local Institution - 0331, Puebla City

72762

RECRUITING

Highlands Oncology Group, Springdale

73657

NOT_YET_RECRUITING

Local Institution - 0114, Tainan City

75014

NOT_YET_RECRUITING

Local Institution - 0429, Paris

75248

NOT_YET_RECRUITING

Local Institution - 0218, Paris

75390

NOT_YET_RECRUITING

Local Institution - 0433, Dallas

76000

NOT_YET_RECRUITING

Local Institution - 0328, Querétaro City

77030

NOT_YET_RECRUITING

Local Institution - 0132, Houston

77380

NOT_YET_RECRUITING

Local Institution - 0377, The Woodlands

79915

NOT_YET_RECRUITING

Local Institution - 0374, El Paso

80131

NOT_YET_RECRUITING

Local Institution - 0105, Napoli

81675

NOT_YET_RECRUITING

Local Institution - 0202, München

83712

NOT_YET_RECRUITING

Local Institution - 0124, Boise

85054

NOT_YET_RECRUITING

Local Institution - 0388, Phoenix

85724

NOT_YET_RECRUITING

Local Institution - 0120, Tucson

85796

NOT_YET_RECRUITING

Local Institution - 0260, Bydgoszcz

90033

NOT_YET_RECRUITING

Local Institution - 0407, Los Angeles

93049

NOT_YET_RECRUITING

Local Institution - 0209, Regensburg

93590

NOT_YET_RECRUITING

Local Institution - 0390, Kuching

94010

NOT_YET_RECRUITING

Local Institution - 0213, Créteil

97213

NOT_YET_RECRUITING

Local Institution - 0164, Portland

97227

NOT_YET_RECRUITING

Local Institution - 0348, Portland

98109

NOT_YET_RECRUITING

Local Institution - 0145, Seattle

99508

RECRUITING

Alaska Oncology and Hematology, Anchorage

100034

NOT_YET_RECRUITING

Local Institution - 0074, Beijing

100142

NOT_YET_RECRUITING

Local Institution - 0049, Beijing

NOT_YET_RECRUITING

Local Institution - 0286, Beijing

100337

NOT_YET_RECRUITING

Local Institution - 0030, Ploieşti

110001

NOT_YET_RECRUITING

Local Institution - 0284, Shenyang

110004

NOT_YET_RECRUITING

Local Institution - 0104, Shenyang

110029

NOT_YET_RECRUITING

Local Institution - 0267, New Delhi

110042

NOT_YET_RECRUITING

Local Institution - 0103, Shenyang

111511

NOT_YET_RECRUITING

Local Institution - 0305, Bogotá

150081

NOT_YET_RECRUITING

Local Institution - 0106, Harbin

200030

NOT_YET_RECRUITING

Local Institution - 0278, Shanghai

200032

NOT_YET_RECRUITING

Local Institution - 0343, Shanghai

200542

NOT_YET_RECRUITING

Local Institution - 0025, Craiova

210000

NOT_YET_RECRUITING

Local Institution - 0352, Nanjing

210009

NOT_YET_RECRUITING

Local Institution - 0279, Nanjing

210029

NOT_YET_RECRUITING

Local Institution - 0386, Nanjing

221002

NOT_YET_RECRUITING

Local Institution - 0264, Varanasi

230002

NOT_YET_RECRUITING

Local Institution - 0306, Montería

230031

NOT_YET_RECRUITING

Local Institution - 0072, Hefei

250117

NOT_YET_RECRUITING

Local Institution - 0051, Jinan

266003

NOT_YET_RECRUITING

Local Institution - 0068, Qingdao

276001

NOT_YET_RECRUITING

Local Institution - 0066, Linyi

310003

NOT_YET_RECRUITING

Local Institution - 0280, Hangzhou

310016

NOT_YET_RECRUITING

Local Institution - 0069, Hangzhou

310022

NOT_YET_RECRUITING

Local Institution - 0054, Hangzhou

330209

NOT_YET_RECRUITING

Local Institution - 0110, Nanchang

350014

NOT_YET_RECRUITING

Local Institution - 0046, Fuzhou

361003

NOT_YET_RECRUITING

Local Institution - 0100, Xiamen

400004

NOT_YET_RECRUITING

Local Institution - 0345, Mumbai

400012

NOT_YET_RECRUITING

Local Institution - 0266, Mumbai

400015

NOT_YET_RECRUITING

Local Institution - 0022, Cluj-Napoca

NOT_YET_RECRUITING

Local Institution - 0023, Cluj-Napoca

407280

NOT_YET_RECRUITING

Local Institution - 0019, Florești

410008

NOT_YET_RECRUITING

Local Institution - 0387, Changsha

410013

NOT_YET_RECRUITING

Local Institution - 0050, Changsha

430023

NOT_YET_RECRUITING

Local Institution - 0048, Wuhan

430079

NOT_YET_RECRUITING

Local Institution - 0059, Wuhan

450000

NOT_YET_RECRUITING

Local Institution - 0107, Zhengzhou

450008

NOT_YET_RECRUITING

Local Institution - 0047, Zhengzhou

500033

NOT_YET_RECRUITING

Local Institution - 0265, Hyderabad

510000

NOT_YET_RECRUITING

Local Institution - 0443, Guangzhou

510515

NOT_YET_RECRUITING

Local Institution - 0061, Guangzhou

518020

NOT_YET_RECRUITING

Local Institution - 0281, Shenzhen

530021

NOT_YET_RECRUITING

Local Institution - 0067, Nanning

550002

NOT_YET_RECRUITING

Local Institution - 0408, Guiyang

560017

NOT_YET_RECRUITING

Local Institution - 0344, Bengaluru

560092

NOT_YET_RECRUITING

Local Institution - 0263, Bangalore

610041

NOT_YET_RECRUITING

Local Institution - 0102, Chengdu

NOT_YET_RECRUITING

Local Institution - 0109, Chengdu

700106

NOT_YET_RECRUITING

Local Institution - 0031, Iași

700483

NOT_YET_RECRUITING

Local Institution - 0026, Iași

710038

NOT_YET_RECRUITING

Local Institution - 0060, Xi'an

1138603

NOT_YET_RECRUITING

Local Institution - 0234, Bunkyo-ku

1834111

NOT_YET_RECRUITING

Local Institution - 0016, Afula

2418515

NOT_YET_RECRUITING

Local Institution - 0238, Yokohama

3109601

NOT_YET_RECRUITING

Local Institution - 0014, Haifa

4428164

NOT_YET_RECRUITING

Local Institution - 0010, Kfar Saba

5265601

NOT_YET_RECRUITING

Local Institution - 0011, Ramat Gan

9013102

NOT_YET_RECRUITING

Local Institution - 0017, Jerusalem

9112001

NOT_YET_RECRUITING

Local Institution - 0013, Jerusalem

9810914

NOT_YET_RECRUITING

Local Institution - 0232, Sendai

14784400

NOT_YET_RECRUITING

Local Institution - 0081, Barretos

15090000

NOT_YET_RECRUITING

Local Institution - 0351, São José do Rio Preto

29055450

NOT_YET_RECRUITING

Local Institution - 0088, Vitória

04074

NOT_YET_RECRUITING

Local Institution - 0127, Scarborough

02215

NOT_YET_RECRUITING

Local Institution - 0158, Boston

84112-5550

NOT_YET_RECRUITING

Local Institution - 0354, Salt Lake City

C1280AEB

NOT_YET_RECRUITING

Local Institution - 0446, Buenos Aires

ACT 2605

NOT_YET_RECRUITING

Local Institution - 0368, Garran

QLD 4102

NOT_YET_RECRUITING

Local Institution - 0373, Woolloongabba

59062-000

NOT_YET_RECRUITING

Local Institution - 0079, Natal

91350-200

NOT_YET_RECRUITING

Local Institution - 0346, Porto Alegre

89010-340

NOT_YET_RECRUITING

Local Institution - 0085, Blumenau

17033-490

NOT_YET_RECRUITING

Local Institution - 0076, Bauru

13060-803

NOT_YET_RECRUITING

Local Institution - 0094, Campinas

09541-270

NOT_YET_RECRUITING

Local Institution - 0355, São Caetano do Sul

01509-010

NOT_YET_RECRUITING

Local Institution - 0095, São Paulo

20231-050

NOT_YET_RECRUITING

Local Institution - 0091, Rio de Janeiro

01246-000

NOT_YET_RECRUITING

Local Institution - 0078, São Paulo

050035

NOT_YET_RECRUITING

Local Institution - 0353, Shijiazhuang

030000

NOT_YET_RECRUITING

Local Institution - 0283, Taiyuan

050030

NOT_YET_RECRUITING

Local Institution - 0330, Medellín

500 05

NOT_YET_RECRUITING

Local Institution - 0251, Hradec Králové

779 00

NOT_YET_RECRUITING

Local Institution - 0250, Olomouc

115 26

NOT_YET_RECRUITING

Local Institution - 0005, Athens

115 27

NOT_YET_RECRUITING

Local Institution - 0001, Athens

115 28

NOT_YET_RECRUITING

Local Institution - 0009, Athens

540 07

NOT_YET_RECRUITING

Local Institution - 0006, Thessaloniki

06132

NOT_YET_RECRUITING

Local Institution - 0044, Perugia

460-0001

NOT_YET_RECRUITING

Local Institution - 0243, Nagoya

277-8577

NOT_YET_RECRUITING

Local Institution - 0236, Kashiwa

373-8550

NOT_YET_RECRUITING

Local Institution - 0334, Otashi

0608648

NOT_YET_RECRUITING

Local Institution - 0233, Sapporo

670-8520

NOT_YET_RECRUITING

Local Institution - 0336, Himeji

650-0047

NOT_YET_RECRUITING

Local Institution - 0247, Kobe

028-3695

NOT_YET_RECRUITING

Local Institution - 0335, Shiwa-gun Yahaba-cho

216-8511

NOT_YET_RECRUITING

Local Institution - 0257, Kawasaki

783-8505

NOT_YET_RECRUITING

Local Institution - 0241, Nankoku

515-8544

NOT_YET_RECRUITING

Local Institution - 0237, Matsusaka

573-1191

NOT_YET_RECRUITING

Local Institution - 0240, Hirakata

350-1298

NOT_YET_RECRUITING

Local Institution - 0245, Hidaka

321-0293

NOT_YET_RECRUITING

Local Institution - 0235, Shimotsuga

755-0241

NOT_YET_RECRUITING

Local Institution - 0242, Ube

811-1395

NOT_YET_RECRUITING

Local Institution - 0246, Fukuoka

701-1192

NOT_YET_RECRUITING

Local Institution - 0244, Okayama

534-0021

NOT_YET_RECRUITING

Local Institution - 0239, Osaka

03100

NOT_YET_RECRUITING

Local Institution - 0293, Mexico City

06760

WITHDRAWN

Local Institution - 0294, Mexico City

5504 DB

NOT_YET_RECRUITING

Local Institution - 0445, Veldhoven

6815 AD

WITHDRAWN

Local Institution - 0230, Arnhem

9713 GZ

NOT_YET_RECRUITING

Local Institution - 0249, Groningen

60-192

NOT_YET_RECRUITING

Local Institution - 0262, Poznan

30-727

NOT_YET_RECRUITING

Local Institution - 0259, Krakow

04-125

NOT_YET_RECRUITING

Local Institution - 0261, Warsaw

82-550

NOT_YET_RECRUITING

Local Institution - 0258, Prabuty

022338

NOT_YET_RECRUITING

Local Institution - 0021, Bucharest

075100

NOT_YET_RECRUITING

Local Institution - 0027, Otopeni

020335

NOT_YET_RECRUITING

Local Institution - 0020, Bucharest

03080

NOT_YET_RECRUITING

Local Institution - 0270, Seoul

03722

NOT_YET_RECRUITING

Local Institution - 0269, Seoul

05505

NOT_YET_RECRUITING

Local Institution - 0268, Seoul

06351

NOT_YET_RECRUITING

Local Institution - 0274, Seoul

08035

NOT_YET_RECRUITING

Local Institution - 0116, Barcelona

08907

NOT_YET_RECRUITING

Local Institution - 0248, Hospitalet

08036

WITHDRAWN

Local Institution - 0253, Barcelona

009035575

NOT_YET_RECRUITING

Local Institution - 0349, Izmir, Karsiyaka

01140

NOT_YET_RECRUITING

Local Institution - 0318, Adana

01370

NOT_YET_RECRUITING

Local Institution - 0317, Adana

06680

NOT_YET_RECRUITING

Local Institution - 0321, Ankara

07059

NOT_YET_RECRUITING

Local Institution - 0350, Antalya

w1g 6ad

NOT_YET_RECRUITING

Local Institution - 0228, London

Sponsors
All Listed Sponsors
lead

Bristol-Myers Squibb

INDUSTRY