NCT07062367View on ClinicalTrials.gov

Sevoflurane With or Without Intravenous Lidocaine Infusion Versus Propofol Anesthesia on Intracranial Pressure and Cerebral Oxygenation During Laparoscopic Hysterectomy

NARecruitingINTERVENTIONAL
Enrollment

90

Participants

Timeline

Start Date

February 1, 2025

Primary Completion Date

February 1, 2027

Study Completion Date

February 1, 2027

Conditions
SevofluraneLidocainePropofolIntracranial PressureCerebral OxygenationLaparoscopic Hysterectomy
Interventions
DRUG

Propofol

Patients' anesthesia will be maintained by manually adjusted propofol infusion at a rate of 100-250 mic/kg/min for bispectral index (BIS) maintained between 40-60.

DRUG

Sevoflurane plus lidocaine infusion

Sevoflurane with monitored anesthesia care (MAC) adjusted to maintain bispectral index (BIS) between 40-60 plus intravenous lidocaine infusion given as 2mg /kg IV bolus before induction then intraoperative infusion by a rate of 2 mg/kg/h until the end of surgery.

DRUG

Sevoflurane

Patients will receive sevoflurane with monitored anesthesia care (MAC) adjusted to maintain bispectral index (BIS) between 40-60.

Trial Locations (1)

31527

RECRUITING

Tanta University, Tanta

All Listed Sponsors
lead

Tanta University

OTHER