A Prospective Multicenter RCT Study of Deep Jugular Lymphovenous Anastomosis in the Treatment of Alzheimer's Disease

PHASE3Not yet recruitingINTERVENTIONAL
Enrollment

186

Participants

Timeline

Start Date

July 31, 2025

Primary Completion Date

January 31, 2027

Study Completion Date

January 31, 2027

Conditions
Alzheimer's Disease
Interventions
PROCEDURE

Deep cervical lymphatic-venous anastomosis

Lymph node reconstruction was carried out using microsurgical techniques,improve cerebral lymphatic circulation and return, accelerate the excretion of pathological proteins, the metabolic products of the brain, from the brain. This is to delay the degenerative changes of the brain and the progression of Alzheimer's disease.

DRUG

Donepezil drug treatment

All patients stopped taking cognitive-enhancing drugs after enrollment, and marketed therapeutic drugs include ginkgo biloba, high-dose vitamin E, lecithin, estrogen, non-steroidal anti-inflammatory drugs, memegan, etc.

All Listed Sponsors
lead

Shanghai Jiao Tong University School of Medicine

OTHER