100
Participants
Start Date
July 1, 2025
Primary Completion Date
December 31, 2025
Study Completion Date
January 31, 2026
Ketamine
Ketamine administered intravenously at 0.15 mg/kg/h via PCA with 1 mg boluses, 5-minute lockout, maximum 500 mg per 24 hours after knee arthroplasty.
Standard Analgesia
Standard analgesia includes ketoprofen 100 mg twice daily and paracetamol 1000 mg every 8 hours for 24 hours after knee arthroplasty; morphine 10 mg IM as needed for rescue therapy.
RECRUITING
Pirogov National Medical and Surgical Center, Moscow
State Budgetary Healthcare Institution, National Medical Surgical Center N.A. N.I. Pirogov, Ministry of Health of Russia
OTHER