FSRT Combines With Bevacizumab for Multiple Brain Metastases in Lung Adenocarcinoma

PHASE3RecruitingINTERVENTIONAL
Enrollment

252

Participants

Timeline

Start Date

June 30, 2025

Primary Completion Date

December 30, 2028

Study Completion Date

December 30, 2028

Conditions
Multiple Brain Metastases in Lung Adenocarcinoma
Interventions
DRUG

Bevacizumab

Bevacizumab starts on day 1 (one week before FSRT treatment), q3w,a total of 4 treatment courses, intravenous injection, with a dose of 7.5mg/kg.

RADIATION

FSRT

The FSRT group received simple FSRT radiotherapy; FSRT is targeted at visible intracranial lesions, with a total dose of 30Gy, administered once a day for a total of 5 days, with a fraction dose of 6Gy.

RADIATION

Whole brain radiotherapy

The WBRT group received whole brain radiotherapy and locally increased dose radiotherapy for visible intracranial lesions, with a total dose of 40Gy for local lesions and 30Gy for the whole brain, once a day for a total of 10 days.

Trial Locations (1)

510000

RECRUITING

Sun yat-sen University Cancer Center, Guangzhou

All Listed Sponsors
lead

Sun Yet-Sen University Cancer Center

OTHER