Probiotic and Prebiotic Use in Early Postoperative Period of Sleeve Gastrectomy

NACompletedINTERVENTIONAL
Enrollment

60

Participants

Timeline

Start Date

January 24, 2025

Primary Completion Date

April 22, 2025

Study Completion Date

June 16, 2025

Conditions
Sleeve GastrectomyGastrointestinal SymptomsPrebioticProbiotic
Interventions
DIETARY_SUPPLEMENT

Probiotic and Prebiotic

"This synbiotic intervention aims to minimize postoperative gastrointestinal symptoms in sleeve gastrectomy patients. The 5 g sachet contains:~* Partially hydrolyzed guar gum (PHGG; 4.9 g): Clinically shown to reduce diarrhea and improve stool consistency,~* Lactobacillus rhamnosus GG (LGG; 1×10⁹ CFU): Evidence-based for alleviating abdominal pain and bloating,~* Maltodextrin (0.1 g): Excipient for stability.~Administered daily in yogurt for 12 weeks post-surgery, this combination directly targets:~① Diarrhea and constipation (via PHGG's soluble fiber),~② Abdominal pain and bloating (via LGG's anti-inflammatory effects),~③ Overall GI symptom burden.~\*\*Distinctive features vs. other studies:~* Symptom-specific formulation: PHGG (high-dose fiber) + LGG (symptom-targeted probiotic) synergy,~* Surgical context: Optimized for rapid gastric transit post-sleeve gastrectomy,~* Delivery innovation: Yogurt matrix protects probiotics against surgical gut pH changes."

Trial Locations (1)

06680

Türk Obezite Cerrahisi Vakfı, Ankara

All Listed Sponsors
lead

Ayten Altunsaray

OTHER_GOV

NCT07051824 - Probiotic and Prebiotic Use in Early Postoperative Period of Sleeve Gastrectomy | Biotech Hunter | Biotech Hunter