Consolidative Local Therapy (CLT) in Oligo-metastatic Urothelial Carcinoma

PHASE2Not yet recruitingINTERVENTIONAL
Enrollment

32

Participants

Timeline

Start Date

October 31, 2025

Primary Completion Date

October 31, 2028

Study Completion Date

October 31, 2028

Conditions
Locally Advanced Urothelial CarcinomaOligo-metastaic Urothelial Carcinoma
Interventions
PROCEDURE

Radical cystectomy

The intervention in this clinical trial consists of definitive surgical management through radical cystectomy with bilateral pelvic lymph node dissection (PLND), urinary diversion, and metastasectomy of surgically resectable or previously radiated metastatic disease. Surgical approach may be either open or robotic, based on surgeon discretion and patient-specific factors. The PLND will be performed in a standard oncologic fashion, including dissection of the common iliac, external iliac, internal iliac, and obturator nodal basins bilaterally. In cases where metastatic lymph nodes are identified beyond these regions, the lymph node dissection may be extended to achieve gross resection of involved nodal disease within the abdomen or retroperitoneum.

Trial Locations (1)

06510

Yale University, New Haven

All Listed Sponsors
collaborator

Medical College of Virginia Foundation

UNKNOWN

lead

Yale University

OTHER