Effect of Bilateral vs. Unilateral Alveolar Recruitment on Gas Exchange in Lung Resection

NANot yet recruitingINTERVENTIONAL
Enrollment

198

Participants

Timeline

Start Date

July 10, 2025

Primary Completion Date

April 10, 2027

Study Completion Date

June 10, 2027

Conditions
Lung Cancer Requiring Surgical Resection Under One-lung Ventilation
Interventions
PROCEDURE

Unilateral ARM

ARM is performed to the dependent lung only. During ARM, mechanical ventilation is set to a pressure-controlled ventilation mode with a driving pressure of 20 cmH₂O and an inspiratory-to-expiratory ratio of 1:1. The positive end-expiratory pressure (PEEP) is increased by 5 cmH₂O every five respiratory cycles, reaching a final PEEP of 20 cmH₂O and a peak airway pressure of 40 cmH₂O, which is then maintained for ten respiratory cycles.

PROCEDURE

Bilateral ARM

ARM is performed to both lungs. During ARM, mechanical ventilation is set to a pressure-controlled ventilation mode with a driving pressure of 20 cmH₂O and an inspiratory-to-expiratory ratio of 1:1. The positive end-expiratory pressure (PEEP) is increased by 5 cmH₂O every five respiratory cycles, reaching a final PEEP of 20 cmH₂O and a peak airway pressure of 40 cmH₂O, which is then maintained for ten respiratory cycles.

Trial Locations (2)

Unknown

Severance Hospital, Yonsei University Health System, Seoul

Severance hospital, Seoul

All Listed Sponsors
lead

Yonsei University

OTHER