NCT07044297View on ClinicalTrials.gov

A Clinical Study of MK-8527 to Prevent Human Immunodeficiency Virus Type 1 (HIV-1) (MK-8527-011)

PHASE3RecruitingINTERVENTIONAL
Enrollment

4,390

Participants

Timeline

Start Date

July 31, 2025

Primary Completion Date

October 20, 2027

Study Completion Date

October 20, 2027

Conditions
Human Immunodeficiency Virus (HIV)HIV Pre-Exposure Prophylaxis
Interventions
DRUG

MK-8527

Oral tablet

DRUG

FTC/TDF

Oral tablet

DRUG

Placebo to MK-8527

Placebo tablet matched to MK-8527

DRUG

Placebo to FTC/TDF

Placebo tablet matched to FTC/TDF

Trial Locations (27)

3010

RECRUITING

Inselspital Bern ( Site 1103), Bern

4031

RECRUITING

University Hospital Basel ( Site 1102), Basel

8005

RECRUITING

Checkpoint Zurich ( Site 1100), Zurich

10104

RECRUITING

CEMDOE - Centro Médico de Diabetes, Obesidad y Especialidades ( Site 1001), Santo Domingo

10147

RECRUITING

Endocardio ( Site 1003), Santo Domingo

10305

RECRUITING

"Instituto Dermatológico y Cirugía de Piel Dr. Huberto Bogaert Díaz ( Site 1002)", Santo Domingo de Guzman

10467

RECRUITING

Montefiore Medical Center ( Site 0017), The Bronx

15213

RECRUITING

University of Pittsburgh Medical Center-Division of Infectious Diseases ( Site 0022), Pittsburgh

19107

RECRUITING

Philadelphia Fight Community Health Centers ( Site 0011), Philadelphia

20009

RECRUITING

Whitman-Walker Institute ( Site 0016), Washington D.C.

27401

RECRUITING

Regional Center for Infectious Diseases ( Site 0018), Greensboro

30030

RECRUITING

Hope Clinic of the Emory Vaccine Center ( Site 0009), Decatur

32803

RECRUITING

Orlando Immunology Center ( Site 0021), Orlando

35222

RECRUITING

University of Alabama at Birmingham-UAB 1917 Research Clinic ( Site 0006), Birmingham

36617

RECRUITING

USA Health University Hospitals ( Site 0020), Mobile

37208

RECRUITING

Meharry Medical College ( Site 0013), Nashville

39202

RECRUITING

Open Arms Healthcare Center ( Site 0025), Jackson

60612

RECRUITING

University of Illinois Chicago ( Site 0027), Chicago

77401

RECRUITING

Saint Hope Foundation, Inc. ( Site 0015), Bellaire

78705

RECRUITING

Central Texas Clinical Research ( Site 0014), Austin

90035

RECRUITING

UCLA Center for Clinical AIDS Research and Education ( Site 0004), Los Angeles

94102

RECRUITING

Bridge HIV - San Francisco Department of Public Health ( Site 0001), San Francisco

98104

RECRUITING

Fred Hutchinson Cancer Center - The Seattle HIV Vaccine Trials Unit ( Site 0002), Seattle

07103

RECRUITING

Rutgers New Jersey Medical School ( Site 0010), Newark

01009

RECRUITING

Clínica Médica Especializada en Pediatría e Infectología Pediátrica - Dr. Mario Melgar ( Site 1051), Guatemala City

RECRUITING

MEDI-K ( Site 1053), Guatemala City

01010

RECRUITING

CELAN,S.A ( Site 1052), Guatemala City

All Listed Sponsors
lead

Merck Sharp & Dohme LLC

INDUSTRY